AI Article Synopsis

  • Recent advancements in CCD video-cameras have led to the development of a compact capillaroscopy, enhancing sensitivity and making it suitable for bedside use.
  • This new instrument includes a CCD video-probe with a contact-type lens and illuminator to observe capillary flow in various skin areas.
  • The study revealed that it can visualize blood flow in nearly all skin regions, and a specific level of stress is needed to halt capillary flow, indicating its potential for clinical applications.

Article Abstract

Recent technological advances of the CCD video-camera have made microscopes more compact and greatly improved their sensitivity. We newly designed a compact capillaroscopy which was composed with a CCD video-probe equipped a contact-type objective lens and illuminator. In the present study, we evaluated usefulness of the instrument for a bed-side human capillaroscopy to observe the capillary flow in various dermal regions. The influences of tissue compression on the dermal capillary blood flow were also investigated to confirm the utility for clinical applications. Our capillaroscopy visualized the nutritional capillary blood flow in almost all parts of skin surface. Our observations showed that a level of vertical stress similar to arterial pressure was required to stop the capillary flow. From these demonstrations the present CCD video-probe based capillaroscopy would be useful for clinical applications as a bed-side human capillaroscopy.

Download full-text PDF

Source
http://dx.doi.org/10.1109/IEMBS.2010.5626131DOI Listing

Publication Analysis

Top Keywords

capillary flow
12
tissue compression
8
ccd video-probe
8
bed-side human
8
human capillaroscopy
8
capillary blood
8
blood flow
8
clinical applications
8
flow
5
capillaroscopy
5

Similar Publications

Hyperpolarized Xe MRI/MRS enables quantitative mapping of function in lung airspaces, membrane tissue, and red blood cells (RBCs) within the pulmonary capillaries. The RBC signal also exhibits cardiogenic oscillations that are reduced in pre-capillary pulmonary hypertension (PH). This effect is obscured in patients with concomitant defects in transfer from airspaces to RBCs, which increase RBC oscillation amplitudes.

View Article and Find Full Text PDF

Clinical Features Evaluation of Myopic Fundus tessellation from OCTA and MfERG.

Photodiagnosis Photodyn Ther

January 2025

Ningbo Eye Hospital, Wenzhou Medical University, Ningbo, Zhejiang, 315000, P.R. China. Electronic address:

Purpose: To evaluate the differences in fundus tessellation among various severities using multifocal visual electrophysiology (MfERG) and optical coherence tomography angiography (OCTA) for clinical grading and treatment.

Methods: This study included 52 patients totaling 87 eyes. The Early Treatment Diabetic Retinopathy Study (ETDRS) grid division method was utilized to assess Grade of fundus tessellation.

View Article and Find Full Text PDF

Tissue nanotransfection-based endothelial PLCγ2-targeted epigenetic gene editing in vivo rescues perfusion and diabetic ischemic wound healing.

Mol Ther

January 2025

Department of Surgery, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, United States; Department of Surgery, Indiana Center for Regenerative Medicine and Engineering, Indiana University School of Medicine, Indianapolis, IN 46202, United States. Electronic address:

Diabetic wounds are complicated by underlying peripheral vasculopathy. Reliance on vascular endothelial growth factor (VEGF) therapy to improve perfusion makes logical sense, yet clinical study outcomes on rescuing diabetic wound vascularization have yielded disappointing results. Our previous work has identified that low endothelial phospholipase Cγ2 (PLCγ2) expression hinders the therapeutic effect of VEGF on the diabetic ischemic limb.

View Article and Find Full Text PDF

Production of Hydrophobic Microparticles at Safe-To-Inject Sizes for Intravascular Administration.

Pharmaceutics

January 2025

Laboratory of Biointerface Chemistry, Department of Molecules and Materials, Faculty of Science and Technology, Technical Medical Centre and MESA+ Institute, University of Twente, 7522NB Enschede, The Netherlands.

Hydrophobic microparticles are one of the most versatile structures in drug delivery and tissue engineering. These constructs offer a protective environment for hydrophobic or water-sensitive compounds (e.g.

View Article and Find Full Text PDF

A Reusable Capillary Flow-Driven Microfluidic System for Abscisic Acid Detection Using a Competitive Immunoassay.

Sensors (Basel)

January 2025

Instituto de Engenharia de Sistemas e Computadores-Microsistemas e Nanotecnologias (INESC-MN), Rua Alves Redol, 1000-029 Lisbon, Portugal.

Point-of-care (PoC) devices offer a promising solution for fast, portable, and easy-to-use diagnostics. These characteristics are particularly relevant in agrifood fields like viticulture where the early detection of plant stresses is crucial to crop yield. Microfluidics, with its low reagent volume requirements, is well-suited for such applications.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!