The cornea is the window of the eye and when it is severely damaged or diseased, vision is impaired. Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK) is a surgical procedure to replace the malfunctioned Descemet's membrane with a healthy one in order to restore the patient's sight. After the operation, ophthalmologists need to monitor the grafted membrane to check for signs of detachment, rejection, etc. and take appropriate actions before graft failure occurs. In this paper, we introduce the COrneaL GrAft Thickness Evaluation (COLGATE) System that we developed for ophthalmologists for the evaluation of the transplanted corneal graft. We discuss the various components in our system and methods we developed. Experiments are conducted and the results are m1 = 7.5% and m2 = 7.2%.
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http://dx.doi.org/10.1109/IEMBS.2010.5626142 | DOI Listing |
Jpn J Ophthalmol
January 2025
Miyata Eye Hospital, 6-3, Kuraharacho, Miyakonojo, 885-0051, Miyazaki, Japan.
Purpose: This study aimed to report the incidence, characteristics, and prognosis of corneal perforation in patients with leprosy.
Study Design: Retrospective observational study.
Methods: Patients who presented with leprosy and visited a specialised ophthalmology hospital (Miyata Eye Hospital, Miyazaki, Japan) between 1980 and 2020 were included.
Eur J Ophthalmol
January 2025
Cornea and Refractive Surgery Unit, Instituto de Microcirugía Ocular (IMO), Barcelona, 08035, Spain.
Sci Rep
January 2025
Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-0016, Japan.
Systemic administration of Janus kinase (JAK) inhibitors is effective in treating chronic graft-versus-host disease (cGVHD) but is associated with side effects. Topical drug administration effectively minimizes side effects. We aimed to investigate potential trends of the efficacy of topical delgocitinib administration in a mouse model.
View Article and Find Full Text PDFPLOS Glob Public Health
December 2024
Laboratory Biology, Engineering and Imaging for Ophthalmology, Health Innovation Campus, Faculty of Medicine, University Jean Monnet, Saint-Etienne, France.
Corneal graft (keratoplasty) is the most common allograft in the world, but the imbalance between the number of donors and the number of patients waiting for transplants is abysmal on a global scale and varies enormously from one country to another. The risk of transmission of systemic diseases from donor to recipient is demonstrably low. In over 50 years and an estimated 2.
View Article and Find Full Text PDFSci Rep
December 2024
Structural Biophysics Research Group, School of Optometry & Vision Sciences, Cardiff University, Cardiff, Wales, UK.
Fuchs' endothelial corneal dystrophy (FECD) is a common sight-threatening condition characterised by pathological changes in the posterior cornea. Here we report observations by light, transmission and volume scanning electron microscopy on changes in the endothelium and matrix associated with the characteristic deformations of Descemet's membrane, termed guttae. Specimens were archived full-thickness human corneal tissue, removed during graft surgery, that had been fixed, stained and embedded by conventional processing methods for examination by transmission electron microscopy more than 40-years previously.
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