The object of this study was to investigate the influence of static and dynamic forces on mechanical properties of the biocompatible polymer ethyl cellulose. Similar polymeric films containing 40% (w/w) of the plasticizer dibutyl sebacate were subjected to tensile forces at different velocities. The average Young's modulus and the variation of yield strength, strain, and strain energy at different velocities complied with the pre-established theories of dynamic loadings. The ultimate strength and the yield strength and/or strain displayed linearity with the velocity, though the ultimate strain and therefore, the plastic and/or ultimate working energies proved non-linear pseudo-Michaelis-Menten behavior. The speculation was that achieving the maximum displacement would probably be the most important cause of failure. Finally the most suitable velocity at which the data would obtain the most demonstrable stress-strain diagrams was selected: tensile forces at almost low velocities, best illustrated as static forces, proved immature failure of the specimens during or shortly after the yield; so that the specimen resembled as a brittle material. High velocities of loadings were also avoided since the strain would usually approach the plateau and would therefore disrupt the rational correlation between forces and displacements during the end region of the curve.
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http://dx.doi.org/10.1016/j.ijpharm.2010.11.031 | DOI Listing |
Matrix Biol Plus
February 2025
Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH 45221, USA.
Schwann cells (SCs) hold key roles in axonal function and maintenance in the peripheral nervous system (PNS) and are a critical component to the regeneration process following trauma. Following PNS trauma, SCs respond to both physical and chemical signals to modify phenotype and assist in the regeneration of damaged axons and extracellular matrix (ECM). There is currently a lack of knowledge regarding the SC response to dynamic, temporal changes in the ECM brought on by swelling and the development of scar tissue as part of the body's wound-healing process.
View Article and Find Full Text PDFMathematical modeling of somatic evolution, a process impacting both host cells and microbial communities in the human body, can capture important dynamics driving carcinogenesis. Here we considered models for esophageal adenocarcinoma (EAC), a cancer that has dramatically increased in incidence over the past few decades in Western populations, with high case fatality rates due to late-stage diagnoses. Despite advancements in genomic analyses of the precursor Barrett's esophagus (BE), prevention of late-stage EAC remains a significant clinical challenge.
View Article and Find Full Text PDFHeliyon
January 2025
Institute of Power Engineering, Riga Technical University, Azenes iela 12/1, Riga, LV, 1048, Latvia.
This paper addresses the participation of independent aggregators (IAs) for demand response (DR) in European electricity markets. An IA is an aggregator trading the flexibility of consumers of which it is not the electricity supplier. Particularly, we focus on the controversial issue of a compensation payment from the IA to the supplier for energy sourcing.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Computer Science and Engineering, Engineering College Ajmer, Ajmer, Rajasthan, India.
To combat dynamically loaded code in anti-emulated environments, DLCDroid is an Android app analysis framework. DL-CDroid uses the reflection API to effectively identify information leaks due to dynamically loaded code within malicious apps, incorporating static and dynamic analysis techniques. The Dynamically Loaded Code (DLC) technique employs Java features to allow Android apps to dynamically expand their functionality at runtime.
View Article and Find Full Text PDFJ Biomech
January 2025
The Joint Department of Biomedical Engineering, the University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; North Carolina State University, Raleigh, NC, United States.
Throughout childhood growth and development, both the nervous and the musculoskeletal systems undergo rapid change. The goal of this study was to examine the impact of growth-related changes in skeletal size and muscle strength on the neural control of finger force generation. By modifying an existing OpenSim hand model in accordance with pediatric anthropometric data, we created 10 distinct models representing males and females at each year of development from 6 to 10 years old.
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