AI Article Synopsis
- Particle-induced osteolysis contributes to aseptic loosening in total joint replacements, prompting a study on macrophages and giant cells' cellular senescence.
- The research found significantly higher levels of senescence (measured by SA-β-Gal) in patients with aseptic loosening compared to those without.
- A correlation was observed between increased SA-β-Gal expression in immune cells and the amount of polyethylene debris, suggesting that wear particles may lead to premature, stress-induced senescence in these cells.
Article Abstract
Particle-induced osteolysis is a major cause of aseptic loosening after total joint replacement. The purpose of the current study was to evaluate cellular senescence of macrophages and giant cells in patients with aseptic hip loosening by determination of SA-β-Gal (SA-β-galactosidase), a reliable and frequently used indicator of cellular senescence. The level of senescence in capsule and interface membranes was significantly higher in patients with aseptic loosening in comparison to specimens from patients without aseptic loosening. Using Spearman's rank correlation, we found that the expression of SA-β-Gal in giant cells (p=0.002) and macrophages (p=0.050) in the interface membranes correlates significantly with the degree of polyethylene debris. We speculate that the induction of DNA damage by wear particles is responsible for premature senescence. Consequently, we conclude that the form of senescence observed in this study is a "stress-induced senescence".
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| http://dx.doi.org/10.1016/j.actbio.2010.11.016 | DOI Listing |
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