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Modulation of T-cell reactivity during equine pregnancy is antigen independent.
Am J Reprod Immunol
August 2012
Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Problem: Pregnant mares demonstrate a reduction in cytotoxic T lymphocyte (CTL) reactivity against cells from the breeding stallion. We investigated whether this effect is limited to activity against paternal major histocompatibility complex (MHC) antigens, and whether it occurs during MHC-compatible pregnancy.
Method Of Study: Mares were mated to carry MHC-compatible or MHC-incompatible pregnancies.
Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cells.
Am J Transplant
July 2007
Department of Medicine, Division of Transplant Immunology and Transplant Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
The outcome of T-cell-mediated responses, immunity or tolerance, critically depends on the balance of cytopathic versus regulatory T (T(reg)) cells. In the creation of stable tolerance to MHC incompatible allografts, reducing the unusually large mass of donor-reactive cytopathic T effector (T(eff)) cells via apoptosis is often required. Cyclosporine (CsA) blocks activation-induced cell death (AICD) of T(eff) cells, and is detrimental to tolerance induction by costimulation blockade, whereas Rapamycin (RPM) preserves AICD, and augments the potential of costimulation blockade to create tolerance.
View Article and Find Full Text PDFImmunologic mechanisms in tolerance produced in mice with nonradiation-based lymphoablation and donor-specific bone marrow.
Transplantation
August 2002
Division of Organ Transplantation, Beth Israel Deaconess Medcial Center, Boston, Massachusetts, USA.
Background: These experiments evaluate the mechanisms associated with tolerance in mice treated with sirolimus, antilymphocyte serum (ALS), and donor-specific bone marrow (BM).
Methods: Tolerance to fully MHC-incompatible skin allografts was induced as follows: C57Bl/10 (H2b) recipients received 0.5 mL of rabbit anti-mouse polyclonal ALS on days -1, +2, and +5 relative to B10.
Transplantation of H-2Kb-transgenic adrenocortical cells in the mouse having undergone an adrenalectomy: functional and morphological aspects.
Transplantation
April 2000
Department of Visceral and Transplantation Surgery, Hanover Medical School, Germany.
Background: A new model of cellular adrenocortical transplantation after bilateral adrenalectomy in the mouse was established. This model was used to study the effects of the expression of the transgenic MHC class I molecule H-2K(b) (Kb) on graft survival and morphologic features, corticosterone secretion, and the possibility of tolerance induction in the recipient.
Method: A single cell suspension of purified adrenocortical cells was grafted under the kidney capsule of B10.
Activation and selection of NK cells via recognition of an allogeneic, non-classical MHC class I molecule, RT1-E.
Eur J Immunol
November 1999
Section of Tumor Immunology, Department of Cell and Molecular Biology, Lund University, Lund, Sweden.
Previous studies have established that NK cells express both inhibitory and activatory receptors. The inhibitory receptors have been shown to recognize major MHC class I molecules, but the physiological ligands for the activatory receptors have been only partly characterized. In this study we investigated whether NK cells could be activated by recognizing specific non-classical MHC class Ib molecules.
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