The use of a membrane and/or a bone graft may not improve the effects of enamel matrix derivatives in infrabony defects.

Article Title And Bibliographic Information: Do bone grafts or barrier membranes provide additional treatment effects for intrabony lesions treated with enamel matrix derivatives? A network meta-analysis of randomized controlled trails. Tu Y-K, Woolston A, Faggion CM Jr. J Clin Periodontol 2010;37:59-79.

Reviewer: Simone Verardi, DDS, MSD.

Purpose/question: Do membranes and bone grafts improve the outcomes in the treatment of intrabony defects when they are used in combination with enamel matrix derivatives?

Source Of Funding: Government: Higher Education Funding Council for England (HEFCE) and United Kingdom Research Council Fellowship.

Type Of Study/design: Systematic review with meta-analysis of data.

Level Of Evidence: Level 2: Limited-quality patient-oriented evidence.

Strength Of Recommendation Grade: Grade B: Inconsistent or limited-quality patient-oriented evidence.