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Visceral adipose tissue accumulation and cardiovascular disease risk profile in postmenopausal women with impaired glucose tolerance or type 2 diabetes. | LitMetric

AI Article Synopsis

  • Women with impaired glucose tolerance (IGT) and type 2 diabetes (T2D) have a higher risk of cardiovascular disease, potentially linked to increased visceral adipose tissue (VAT).
  • A study involving 113 women categorized them based on glucose tolerance and VAT levels, measuring factors like insulin sensitivity, triglycerides, HDL cholesterol, and inflammatory markers.
  • Results showed that higher VAT was associated with lower insulin sensitivity and adverse lipid profiles in IGT women, while T2D women exhibited unique dyslipidemia patterns requiring further investigation beyond just VAT levels.

Article Abstract

Objective: Women with impaired glucose tolerance (IGT) and type 2 diabetes (T2D) are more at risk of cardiovascular disease. The aim of this study was to test the hypothesis that increased visceral adipose tissue (VAT) could explain to a large extent alterations in the cardiovascular disease risk profile of postmenopausal women with IGT or T2D.

Design, Patients And Measurements: Sixty-two women with normal glucose tolerance (NGT), 33 with IGT and 18 with de novo diagnosed T2D were tested. The sample was further divided into five groups: (i) NGT-low VAT (<130 cm(2) ); (ii) NGT-high VAT (≥130 cm(2)); (iii) IGT-low VAT (<130 cm(2) ); (iv) IGT-high VAT (≥130 cm(2) ) and (v) T2D.

Results: Women with T2D, women with IGT-high VAT and those with NGT-high VAT all had lower insulin sensitivity as determined by the euglycaemic-hyperinsulinaemic clamp (M_I), higher triglyceride (TG), lower HDL(2)-cholesterol (chol) levels and higher levels of high-sensitivity C-reactive protein than women with NGT-low VAT. Only differences in M_I and early insulin response (EIR) were observed between women with IGT-high VAT and those with NGT-high VAT (lower values in IGT-high VAT). Women with T2D had lower M_I and EIR as well as higher plasma TG and lower plasma Apo A1 and HDL-chol concentrations than women with NGT-high VAT.

Conclusions: Our results suggest that increase in VAT accumulation usually found in women with IGT explains to a large extent the deterioration in their plasma lipid-lipoprotein and inflammatory profile. However, factors other than VAT are involved in explaining the high TG-low HDL dyslipidaemia observed in women with T2D.

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Source
http://dx.doi.org/10.1111/j.1365-2265.2010.03933.xDOI Listing

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