The reliability of shorter nitrogen balance determinations was evaluated in order to facilitate the nutritional assessment of parenterally fed infants. The intraindividual day-to-day variations of nitrogen intake, excretion, and retention were analyzed in 23 parenterally fed newborn infants (birth weight: 785-2630 g). Nitrogen retentions measured over 3 consecutive days were highly correlated (r = 0.90-0.96), and the reliability for a single 24-hr collection was estimated by r1 = 0.93. Nitrogen balance data obtained over a 24-hr period are reliable for the purpose of clinical investigations, provided the nutrient intake is constant.
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