Facile synthesis of Raman active phospholipid gold nanoparticles.

Bioconjug Chem

Institute of Biomaterials and Biomedical Engineering, Department of Medical Biophysics, and Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.

Published: December 2010

Gold nanoparticle-based surface-enhanced Raman scattering (SERS) probes have shown promise for disease detection and diagnosis. To improve their structural and functional stability for in vivo applications, we synthesized a colloidal SERS gold nanoparticle that encapsulates Raman molecules adsorbed on 60 nm gold with a nonthiol phospholipid coating. Transmission electron microscopy and Raman and UV spectroscopy validated its reproducibility and stability. This novel lipid-based SERS probe provides a viable alternative to the PEGylation and silica coating strategies.

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http://dx.doi.org/10.1021/bc100386aDOI Listing

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