A biocatalytic cascade reaction was designed for the stereoselective synthesis of optically pure 2-alkyl-1,3-diols employing two enzymes. The cascade process consists of two consecutive steps: a stereoselective diketone reduction and a hydroxy ketone reduction. Chiral diols were formed by the addition of ketoreductases in the same vessel, in high stereoselectivity and chemical yield, without the isolation of the intermediate β-hydroxy ketones.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/jo101519t | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Fully Automated Production of ((()-1-Carboxy-5-(6-([F]fluoro)-2-methoxynicotinamido)pentyl)carbamoyl)-l-glutamic Acid ([F]JK-PSMA-7).
Pharmaceuticals (Basel)
January 2025
Forschungszentrum Jülich GmbH, Institute of Neuroscience and Medicine, Nuclear Chemistry (INM-5), Wilhelm-Johnen-Str., 52428 Jülich, Germany.
The radiotracer [F]JK-PSMA-7, a prostate cancer imaging agent for positron emission tomography (PET), was previously synthesized by indirect radiofluorination using an F-labeled active ester as a prosthetic group, which had to be isolated and purified before it could be linked to the pharmacologically active Lys-urea-Glu motif. Although this procedure could be automated on two-reactor modules like the GE TRACERLab FX2N (FXN) to afford the tracer in modest radiochemical yields (RCY) of 18-25%, it is unsuitable for cassette-based systems with a single reactor. To simplify implementation on an automated synthesis module, the radiosynthesis of [F]JK-PSMA-7 was devised as a one-pot, two-step reaction.
View Article and Find Full Text PDFI-Promoted Synthesis of N-Heteroaromatic Benzothiazoles and 2,2'-Biquinolines via Deaminative Cyclization of Tertiary Amines.
Chemistry
January 2025
Key Laboratory of Special Functional Aggregated Materials, Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, People's Republic of China.
A straightforward I-promoted Povarov multicomponent reaction strategy for the synthesis of N-heteroaromatic benzothiazoles and 2, 2'-biquinolines was described. This methodology involved a one-pot two-step procedure, tandem iodination/Kornblum oxidation, and [4+2] condensation. This protocol was characterized by broad scope of substrates (49 examples, 31-80 % yields), applicable for large-scale preparation, and downstream derivatization of the products.
View Article and Find Full Text PDFExploiting photopolymerization to modulate liquid crystalline network actuation.
Soft Matter
January 2025
LENS (European Laboratory for Non-Linear Spectroscopy) Via Nello Carrara 1, 50019 Sesto Fiorentino (FI), Italy.
Liquid Crystalline Networks (LCNs) are widely investigated to develop actuators, from soft robots to artificial muscles. Indeed, they can produce forces and movements in response to a plethora of external stimuli, showing kinetics up to the millisecond time-scale. One of the most explored preparation technique involves the photopolymerization of an aligned layer of reactive mesogens.
View Article and Find Full Text PDFEfficient amine-assisted CO hydrogenation to methanol co-catalyzed by metallic and oxidized sites within ruthenium clusters.
Nat Commun
January 2025
Zhejiang Key Laboratory of Advanced Fuel Cells and Electrolyzers Technology, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, Zhejiang, PR China.
Amine-assisted two-step CO hydrogenation is an efficient route for methanol production. To maximize the overall catalytic performance, both the N-formylation of amine with CO (i.e.
View Article and Find Full Text PDFSimple and Efficient Synthesis of -Succinimidyl-4-[F]fluorobenzoate ([F]SFB)-An Important Intermediate for the Introduction of Fluorine-18 into Complex Bioactive Compounds.
Pharmaceuticals (Basel)
December 2024
N. P. Bechtereva Institute of the Human Brain, Russian Academy of Sciences, 197022 St. Petersburg, Russia.
-succinimidyl-[F]fluorobenzoate ([F]SFB) is commonly prepared through a three-step procedure starting from [F]fluoride ion. A number of methods for the single-step radiosynthesis of [F]SFB have been introduced recently, including the radiofluorination of diaryliodonium salts and the Cu-mediated F-fluorination of pinacol aryl boronates and aryl tributyl stannanes, but they still have the drawbacks of lengthy product purification procedures. In the present work, two approaches for the direct labeling of [F]SFB from diaryliodonium (DAI) salt () and pinacol aryl boronate () are evaluated, with a major focus on developing a fast and simple SPE-based purification procedure.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!