Generalized peritonitis is one of the most adequate clinical models of inflammatory processes with pronounced polyorgan insufficiency in which immunological reactivity may be substantially modified by any intoxicant of exogenous origin, e.g., alcohol. The aim of the present work was to assess immunological status of patients with generalized peritonitis associated with acute and chronic alcoholic intoxication treated by discrete plasmapheresis. A total of 152 men (mean age 49.7 +/- 1.2 years) were examined in Novosibirsk city clinical hospital No 2. Peritonitis developed within the average of 48.2 hours. All the patients with peritonitis experienced a change of immunological responsiveness under effect of such powerful complicating factor as alcoholic intoxication.
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