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[P-PAT regulates AMPA receptor trafficking through PSD-95 palmitoylation].
Tanpakushitsu Kakusan Koso
March 2008
Identification of PSD-95 palmitoylating enzymes.
Neuron
December 2004
Department of Physiology, University of California at San Francisco, San Francisco, California 94143, USA.
Palmitoylation is a lipid modification that plays a critical role in protein trafficking and function throughout the nervous system. Palmitoylation of PSD-95 is essential for its regulation of AMPA receptors and synaptic plasticity. The enzymes that mediate palmitoyl acyl transfer to PSD-95 have not yet been identified; however, proteins containing a DHHC cysteine-rich domain mediate palmitoyl acyl transferase activity in yeast.
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