[Efficiency of emoxipine in treatment of multiple organ failure in newborns].

Prospective, placebo-controlled, simple "blind" randomized study of the effect of emoxipine (2-ethyl-6-methyl-3-oxypyridine hydrochloride) on the dynamics of central hemodynamics, content of lipid peroxidation products in tracheo-bronchial lavage, and severity of clinical sickness was performed in newborn children with multiple organ failures (MOF). The obtained results showed that a 10-day course of the intravenous administration of emoxipine in a single dose of 10 mg/kg improved the systolic function of myocardium of left ventricle, limited lipid peroxidation in broncho-pulmonary system, and increased oxygen delivery to tissues. These effects of emoxipine were accompanied by a clinically significant improvement of neurological status, reduction of the need for artificial ventilation of lungs, and decrease of mortality in newborns with MOF diagnosis.