Aim: To study an association of the serum level of apolipoprotein E (apo-E) with risk factors for coronary heart disease (CHD), blood lipids and that with CHD and carotid artery (CA) atherosclerotic lesion in Kyrgyz men with dyslipidemia.
Subjects And Methods: One hundred and three Kyrgyz men, including 48 with CHD and 55 without this disease, were examined. A clinical examination was performed and blood lipid composition and serum glucose and apo-E levels were determined. The diagnosis of CHD was established in accordance with the conventional criteria. Whether atherosclerosis was present was determined by ultrasound duplex scanning.
Results: Low serum apo-E concentrations were associated with the presence of obesity, the higher blood levels of glucose and triglycerides. There was no correlation with other lipid metabolic parameters and the presence of CHD. A nonlinear relationship was noted between serum apo-E levels and CA atherosclerotic lesion, which was more frequently observed in patients with the apo-E level in the lower and upper quartiles.
Conclusion: Low serum apo-E content is a poor factor and associated with obesity, hypertriglyceridemia, elevated serum glucose levels, and the development of CA atherosclerosis.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
[Structural and functional features of the main arteries of the brain and tumor necrosis factor-alpha in people with chronic non-infectious diseases].
Zh Nevrol Psikhiatr Im S S Korsakova
December 2024
Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan.
Objective: To investigate the structural and functional characteristics of the carotid and vertebral arteries and their relationship with tumor necrosis factor-alpha (TNF-α) levels in patients with chronic non-infectious diseases (CNIDs), considering sex differences.
Unlabelled: Material and Methods. A retrospective analysis of clinical and laboratory data of 760 patients with chronic non-communicable diseases (average age 52.
Adaptation Potential and Body Mass Index in Assessing the Vital Activity of the Population in Mountain Regions.
Iran J Public Health
August 2024
Department of Fundamental Disciplines, International Higher School of Medicine, Bishkek, Kyrgyz Republic.
Background: We aimed to evaluate the functional state of the population of the midlands and highlands of Alai region (Kyrgyzstan) on the basis of body mass index (BMI) and adaptation potential (AP). The characteristic of people with overweight and underweight are presented. A clean dependence of AP on BMI was revealed.
View Article and Find Full Text PDFActivity limitations, use of assistive devices, and mortality and clinical events in 25 high-income, middle-income, and low-income countries: an analysis of the PURE study.
Lancet
August 2024
Population Health Research Institute, McMaster University, Hamilton Health Sciences, ON, Canada.
Article Synopsis
- The study aims to investigate the prevalence of activity limitations and the use of assistive devices across 25 countries with varying economic statuses, focusing on how these limitations correlate with negative health outcomes.
- Researchers analyzed data from the Prospective Urban Rural Epidemiological (PURE) study, which involved over 175,000 participants aged 35-70, looking specifically at self-reported difficulties in daily functions, as well as demographic factors.
- The findings highlight a gap in understanding the relationship between activity limitations and mortality or clinical events, revealing the need for more comprehensive studies on how such limitations impact health across different populations.
A cross-sectional assessment of injection of "salts" and HIV transmission-related behaviours among a cohort of people who inject drugs in Kyrgyzstan.
J Int AIDS Soc
July 2024
School of Medicine, University of California San Diego, La Jolla, California, USA.
Introduction: Despite the increasing availability of new psychoactive substances (hereafter referred to as "salts") in Eastern Europe and Central Asia, there is a dearth of epidemiological data on the relationship between injecting "salts" and HIV risk behaviours. This is particularly relevant in settings where injection drug use accounts for a substantial proportion of the HIV burden, such as in Kyrgyzstan, a former Soviet Republic. This study assessed whether injecting "salts" is associated with sexual and injection-related HIV risk behaviours among people who inject drugs in Kyrgyzstan.
View Article and Find Full Text PDFPrevalence and target attainment of traditional cardiovascular risk factors in patients with systemic lupus erythematosus: a cross-sectional study including 3401 individuals from 24 countries.
Lancet Rheumatol
July 2024
Rheumatology Unit, First Department of Propaedeutic Internal Medicine, Joint Academic Rheumatology Program, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece. Electronic address:
Article Synopsis
- Systemic lupus erythematosus (SLE) significantly increases the risk of cardiovascular disease, prompting a study to evaluate traditional cardiovascular risk factors in SLE patients worldwide between 2015 and 2020.
- The study included 3,401 SLE patients from 24 countries, predominantly women, revealing high rates of hypertension (35.6%), obesity (23.7%), and hyperlipidaemia (19.8%), with poor control of these risk factors across the board.
- Notably, patients with antiphospholipid syndrome had higher prevalence of cardiovascular risks but showed better control of blood pressure and lipid levels compared to those without, highlighting international discrepancies in risk factor management.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!