Objective: To assess the ability of multidetector-row helical computed tomography to depict the esophageal artery.
Methods: Patients with esophageal cancer (n = 88) underwent multidetector-row helical computed tomography. Degree of visualization, branching level, angle, and length of the esophageal artery were investigated.
Results: In 79 (89.8%) of 88 patients, a total of 146 esophageal arteries were delineated from the origin to the insertion into the esophagus. Of the 146 arteries, 112 (76.7%) originated from the descending aorta and 34 (23.3%) from the right intercostal artery. Of the 112 aorta-originated arteries, 110 (98.2%) originated at a level between T6 and T11 from the left side of the descending aorta to go into the left wall of the esophagus. Of the 34 intercostal-originated arteries, 27 (79.4%) originated from right intercostal arteries between T5 and T7 to go into the esophagus.
Conclusions: Multi-detector-row helical computed tomography depicted the esophageal artery in a high percentage of the patients.
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http://dx.doi.org/10.1097/RCT.0b013e3181ed9cf4 | DOI Listing |
The relentless emergence of antibiotic-resistant pathogens, particularly Gram-negative bacteria, highlights the urgent need for novel therapeutic interventions. Drug-resistant infections account for approximately 5 million deaths annually, yet the antibiotic development pipeline has largely stagnated. Venoms, representing a remarkably diverse reservoir of bioactive molecules, remain an underexploited source of potential antimicrobials.
View Article and Find Full Text PDFBinding of transcription factors (TFs) at gene regulatory elements controls cellular epigenetic state and gene expression. Current genome-wide chromatin profiling approaches have inherently limited resolution, complicating assessment of TF occupancy and co-occupancy, especially at individual alleles. In this work, we introduce Accessible Chromatin by Cytosine Editing Site Sequencing with ATAC-seq (ACCESS-ATAC), which harnesses a double-stranded DNA cytosine deaminase (Ddd) enzyme to stencil TF binding locations within accessible chromatin regions.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
School of Physical Science and Technology, Ningbo University, Ningbo 315211, China; Department of Physics and Astronomy, Clemson University, Clemson, SC 29634, United States. Electronic address:
Human calcitonin (hCT) is a peptide hormone that regulates calcium homeostasis, but its abnormal aggregation can disrupt physiological functions and increase the risk of medullary thyroid carcinoma. To elucidate the mechanisms underlying hCT aggregation, we investigated the self-assembly dynamics of hCT segments (hCT, hCT, and hCT) and the folding and dimerization of full-length hCT through microsecond atomistic discrete molecular dynamics (DMD) simulations. Our results revealed that hCT and hCT predominantly existed as isolated monomers with transient small-sized oligomers, indicating weak aggregation tendencies.
View Article and Find Full Text PDFProteins
January 2025
Department of Chemistry, Indian Institute of Technology Bombay, Mumbai, India.
Short-length peptides are used as therapeutics due to their high target specificity and low toxicity; for example, peptides are designed for targeting the interaction between oncogenic protein p53 and E3 ubiquitin ligase MDM2. These peptide therapeutics form a class of successful inhibitors. To design such peptide-based inhibitors, stapling is one of the methods in which amino acid side chains are stitched together to get conformationally rigid peptides, ensuring effective binding to their partners.
View Article and Find Full Text PDFSci Rep
January 2025
Medical Physics, Clinic for Radiology, University of Münster and University Hospital of Münster, 48149, Münster, Albert-Schweitzer-Campus 1, Building A1, Germany.
This study aims to improve our understanding of acute ischemic stroke clot imaging by integrating CT attenuation information with MRI susceptibility signal of thrombi. For this proof-of-principle experimental study, fifty-seven clot analogs were produced using ovine venous blood with a broad histological spectrum. Each clot analog was analyzed to determine its RBC content and chemical composition, including water, Fe III, sodium, pH, and pO2.
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