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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020456 | PMC |
| http://dx.doi.org/10.1128/JCM.01795-10 | DOI Listing |
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Expression Analysis of Cyst Specific Protein (CSP21) and Cellulose Synthase II (CSII) Genes in Acanthamoeba castellanii Trophozoites Exposed to Silver Nanoparticles Conjugated with Elaeagnus umbellata.
Acta Parasitol
January 2025
Department of Molecular Biology and Genetics, Ordu University, Ordu, Turkey.
Article Synopsis
- Acanthamoeba species are protozoa that can cause serious eye and CNS infections, and current treatments are often ineffective, especially in specific areas like the eye.
- The study evaluates the effectiveness of ethanolic fruit extract of E. umbellata, silver nanoparticles derived from it, and lauric acid in killing Acanthamoeba trophozoites and protecting DNA from damage.
- Results show that these treatments can significantly kill trophozoites and prevent DNA damage, suggesting potential new options for treating Acanthamoeba infections.
subsp. Ethanolic Extract Indicated In Vitro Anti- Effect.
Microorganisms
November 2024
Department of Basic and Clinical Sciences, University of Nicosia Medical School, CY-1700 Nicosia, Cyprus.
This study aims to investigate three endemic ethanolic leaf extracts from Cyprus for anti- activities: subsp. (Boiss.) Bolliger, subsp.
View Article and Find Full Text PDFComparative efficacy of extract delivery PEG--PCL, niosome, and their combination against genotype T4: characterization, inhibition, anti-adhesion, and cytotoxic activity.
PeerJ
November 2024
School of Allied Health Sciences, Southeast Asia Water Team (SEA Water Team), World Union for Herbal Drug Discovery (WUHeDD), and Research Excellence Center for Innovation and Health Products (RECIHP), Walailak University, Thasala, Nakhon Si Thammarat, Thailand.
Background: spp. is a waterborne, opportunistic protozoan that can cause amebic keratitis and granulomatous amebic encephalitis. is a native tree in Malaysia, and its extracts possess a broad range of biological activities.
View Article and Find Full Text PDFPlants of the family Lamiaceae as a source of therapeutic agents against Acanthamoeba infections.
Mem Inst Oswaldo Cruz
November 2024
Comenius University in Bratislava, Faculty of Natural Sciences, Department of Zoology, Bratislava, Slovakia.
Background: Acanthamoebae are causative agents of severe and complicated human infections without a standard effective therapy to date. Therefore, the research is focused on the development of new amoebicidal drugs based on the natural products. Plants of the family Lamiaceae are typical with several phenolic secondary metabolites that make them interesting in medical point of view.
View Article and Find Full Text PDFEfficacy of different disinfecting methods for contact lenses against Acanthamoeba castellanii.
Cont Lens Anterior Eye
November 2024
Department of Optometry and Vision, Faculty of Optics and Optometry, Universidad Complutense de Madrid, Madrid, Spain; Ocupharm Group Research, Faculty of Optics and Optometry, Universidad Complutense de Madrid, 28037 Madrid, Spain. Electronic address:
Purpose: To analyze the efficacy of different disinfecting methods for contact lenses (CL) against Acanthamoeba castellanii (AC) using quantitative PCR (qPCR) based on RNA detection.
Methods: Three CL materials: rigid gas permeable (RGP), hydrogel (Hy), and silicone hydrogel (SiHy), were contaminated with 1x10 amoebae/ml and incubated for 24 h at 30 °C. After contamination, pre-cleaning steps were performed before using four maintenance solutions based on hydrogen peroxide (HP), sodium hypochlorite (SH), povidone-iodine (PI), and a multipurpose solution (MS).
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