The development and synthesis of potent p38α MAP kinase inhibitors containing a pyridazinone platform is described. Evolution of the p38α selective pyridopyridazin-6-one series from the p38α/β dual inhibitor 2H-quinolizin-2-one series will be discussed in full detail.
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| http://dx.doi.org/10.1016/j.bmcl.2010.10.128 | DOI Listing |
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