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Kaempferol restores the susceptibility of ESBLs to Ceftiofur.
Front Microbiol
December 2024
College of Veterinary Medicine, Northwest A&F University, Yangling, China.
Introduction: The development of extended-spectrum-beta-lactamase (ESBLs) () has become a global threat to public health. An alternative strategy to alleviate this is identifying potential natural compounds to restore antibiotic activity against ESBLs . This study aimed to find a possible compound to restore ESBLs sensitivity to ceftiofur.
View Article and Find Full Text PDFalleviates experimentally acetic acid- induced ulcerative colitis in rats: targeting CB1/SIRT/MAPK signaling pathways.
Immunopharmacol Immunotoxicol
December 2024
Pharmacology Department, Medical Research and Clinical Studies Institute, National Research Center, Cairo, Egypt.
Background: Ulcerative colitis (UC) is a frequent inflammatory bowel disease (IBD) that causes long-lasting inflammation in the innermost lining of the rectum and colon.
Objective: The aim of this study was to evaluate the therapeutic effect of () on the amelioration of acetic acid-induced colitis in rats.
Materials And Methods: Group 1: normal control group was intrarectally administered saline solution (0.
Protective Effects of Kaempferol on Hepatic Apoptosis via miR-26a-5p Enhancement and Regulation of TLR4/NF-κB and PKCδ in a Rat Model of Non-Alcoholic Fatty Liver.
J Nutr Biochem
December 2024
Departments of Physiology, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.
This study aimed to evaluate kaempferol's, a dietary flavonoid widely present in plants, potential impact on nonalcoholic fatty liver disease (NAFLD) and its underlying mechanisms. In this study, 60 adult male rats were used and divided into a control group receiving a standard pellet diet, a kaempferol-treated group receiving kaempferol (250 mg/kg), a high-fat diet (HFD) group receiving HFD, and a kaempferol-treated HFD group. At the end of the experiment, the total lipid profile and liver enzymes were assayed in the serum.
View Article and Find Full Text PDFThe Anti-Inflammatory Properties of Polysaccharides Extracted from Leaves on IEC6 Cells Stimulated with Lipopolysaccharide In Vitro.
Animals (Basel)
December 2024
College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
() is a plant with significant medicinal and nutritional value and contains various bioactive compounds, particularly in its leaves (MOL). This study sought to explore the impact of leaf polysaccharides (MOLPs) on lipopolysaccharide (LPS)-activated intestinal epithelial cells (IEC6) and to uncover the mechanisms involved. The cytotoxicity of MOLP on IEC6 cells was assessed using the Cell Counting Kit-8 (CCK-8) assay, which demonstrated a safe concentration range of 0-1280 µg/mL.
View Article and Find Full Text PDFSesamol protects against LPS-induced inflammation in rat peritoneal macrophages by promoting SIRT1-induced repression of NF-κB.
Physiol Int
December 2024
1Department of Biochemistry, University of Kerala, Thiruvananthapuram, Kerala 695581, India.
Objectives: Sesamol, a polyphenolic compound isolated from roasted sesame seeds exhibits significant anti-inflammatory effect, but the molecular mechanism is poorly understood. Peritoneal macrophages play a pivotal role in the control of infections and inflammatory pathologies and are also found in injured tissues along with resident macrophages. The present study aimed to examine the anti-inflammatory effect of sesamol and the molecular mechanisms involved, particularly the role of sesamol in modulating SIRT1- and SIRT1-mediated deacetylation of NF-κB p65 using in vivo activated peritoneal macrophages.
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