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Characterizing progenitor cells in developing and injured spinal cord: Insights from single-nucleus transcriptomics and lineage tracing.
Proc Natl Acad Sci U S A
January 2025
State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100080, China.
Various mature tissue-resident cells exhibit progenitor characteristics following injury. However, the existence of endogenous stem cells with multiple lineage potentials in the adult spinal cord remains a compelling area of research. In this study, we present a cross-species investigation that extends from development to injury.
View Article and Find Full Text PDFSocial jetlag and sleep habits in children and adolescents: Associations with autonomy (bedtime setting and electronics curfew) and electronic media use before sleep.
Chronobiol Int
January 2025
Department of Experimental Psychology, University of Oxford, Oxford, UK.
For young people attending school, social jetlag (SJL) refers to discrepancy in sleep/wake timing between school days and weekends. This study investigated SJL in school-aged children and adolescents in England and whether this is associated with age, gender, and sleep habits including bedtimes and electronic media use. Students (school y 5-13; typical age 9-18 y) completed the 2021 OxWell Student Survey.
View Article and Find Full Text PDFFrom Genes to Metabolites: HSP90B1's Role in Alzheimer's Disease and Potential for Therapeutic Intervention.
Neuromolecular Med
January 2025
Department of Neurology, Second Affiliated Hospital of Army Medical University (Xinqiao Hospital), Chongqing, China.
Alzheimer's disease (AD) is a prototypical neurodegenerative disorder, predominantly affecting individuals in the presenile and elderly populations, with an etiology that remains elusive. This investigation aimed to elucidate the alterations in anoikis-related genes (ARGs) in the AD brain, thereby expanding the repertoire of biomarkers for the disease. Using publically available gene expression data for the hippocampus from both healthy and AD subjects, differentially expressed genes (DEGs) were identified.
View Article and Find Full Text PDFRacial/ethnic differences in trends of testicular germ cell tumor incidence in the United States, 1992-2021.
Cancer
January 2025
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Background: Testicular germ cell tumors (TGCTs) are the most common cancers among young men in the United States. Incidence rates among non-Hispanic White (NHW) men historically have been much higher than the rates among other men. To study whether this pattern had changed, the authors examined trends in TGCT incidence for the years 1992-2021.
View Article and Find Full Text PDFAdolescents and young adults with social withdrawal in France: Sociodemographic characteristics and validation of the French version of the Hikikomori Questionnaire-25 (HQ-25).
Int J Soc Psychiatry
January 2025
Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière University Hospital, AP-HP.Sorbonne-Université, Paris, France.
Background: Clinical situations marked by severe social withdrawal in youths are increasingly recognized as an important public health issue in European countries, while the relation with the hikikomori syndrome initially described in Japan remains poorly investigated.
Aims: This study aims to describe the sociodemographic features of adolescents and young adults with social withdrawal in French and to validate a French version of the Hikikomori Questiuonnaire-25 (HQ-25).
Method: An online questionnaire was completed by 450 participants aged 13 to 25 years.
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