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The Microbiome in Asthma Heterogeneity: The Role of Multi-Omic Investigations.
Immunol Rev
March 2025
Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Asthma is one of the most prevalent and extensively studied chronic respiratory conditions, yet the heterogeneity of asthma remains biologically puzzling. Established factors like exogenous exposures and treatment adherence contribute to variability in asthma risk and clinical outcomes. It is also clear that the endogenous factors of genetics and immune system response patterns play key roles in asthma.
View Article and Find Full Text PDFDiscovery of magnetic field line dependent anisotropic chemiresistive response in magnetite: a new piece to the puzzle of magnetoreception.
Mater Horiz
March 2025
CSIR-Central Glass and Ceramic Research Institute, Jadavpur, Kolkata-700032, India.
Chemiresistive materials, which alter their electrical resistance in response to interactions with surrounding chemicals, are valued for their robustness, rapid detection ability and high sensitivity. Recent research has revealed that the sensing performance of these materials can be enhanced by applying an external magnetic field. In this study, we report a novel finding in the chemiresistive behaviour of magnetite (FeO), where its response has been found to be modulated in an anisotropic manner when exposed to an external magnetic field, analogous to Earth's magnetic field.
View Article and Find Full Text PDFLoreX: A Low-Energy Region Explorer Boosts Efficient Crystal Structure Prediction.
J Am Chem Soc
March 2025
Eastern Institute of Technology, Ningbo 315200, China.
Machine learning has boosted the remarkable development of crystal structure prediction (CSP), greatly accelerating modern materials design. However, slow location of the low-energy regions on the potential energy surface (PES) is still a key bottleneck for the overall search efficiency. Here, we develop a low-energy region explorer (LoreX) to rapidly locate low-energy regions on the PES.
View Article and Find Full Text PDFLiquid Bridge Cutting Valves for Microfluidic Passive Distribution and Sequential Reaction.
Small
March 2025
School of Biomedical Engineering, Tsinghua University, Beijing, 100084, China.
In bioanalysis, precisely isolating liquid reactions in distinct systems or at different temporal sequences is vital for ensuring accurate results devoid of crosstalk. However, passive liquid isolation is unattainable through existing microfluidic valves. Here, liquid bridge cutting valves (LBCVs) are introduced to automatically segregate liquids by establishing airlocks, offering an innovative microfluidic structure for liquid distribution.
View Article and Find Full Text PDFSpeciation of Tc-Gluconate Complexes in Aqueous Systems.
Inorg Chem
March 2025
Institut für Nukleare Entsorgung (INE), Karlsruher Institut für Technologie (KIT), Campus Nord, Hermann von Helmholtzplatz 1, 76344 Eggenstein-Leopoldshafen, Germany.
Tc-gluconate complexes in aqueous systems were recently reported and characterized by Tc L-edge X-ray absorption near-edge structure (XANES) measurements [Dardenne, K.; 2021, 60, 12285-12298]. The puzzling result was reported that the Tc L-edge XANES of the sample containing Tc(IV)-gluconate species differs substantially from that of the Tc(IV)O(am,hyd) hydrous oxide reference sample, whereas the Tc K-edge XANES spectra did not differ significantly.
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