AI Article Synopsis
- Advances in molecular genetics are enhancing techniques to study gene function and create mouse models for human diseases.
- The use of knock-in strategies is becoming increasingly important in these developments.
- A focus is placed on recombinase-mediated cassette exchange, a novel method that allows for the efficient creation of multiple different knock-in mutations in a single gene.
Article Abstract
Molecular genetic strategies to study gene function in mice or to generate a mouse model for a human disease are continuously under development. The application and importance of knock-in approaches are increasing. This chapter elaborates on novel developments for the generation of knock-in mice. Special emphasis is given to recombinase-mediated cassette exchange, a new emerging knock-in strategy that enables easy generation of a series of different knock-in mutations within one gene.
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| http://dx.doi.org/10.1007/978-1-60761-974-1_15 | DOI Listing |
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