AI Article Synopsis
- The text discusses how the lipid peroxidation product 4-hydroxy-trans-2-nonenal (4-HNE) affects cell functions in both normal and disease states.
- It examines the metabolism of 4-HNE in tissues, highlighting the crucial role of the glutathione system.
- Additionally, 4-HNE is shown to influence cell growth, differentiation, and apoptosis, and its toxicity during oxidative stress is linked to various diseases due to its ability to modify proteins and nucleic acids.
Article Abstract
The role of lipid peroxidation product 4-hydroxy-trans-2-nonenal (4-HNE) in functional activity of cells under normal and different pathological conditions is discussed. Different pathways of 4-HNE metabolism in tissues are analyzed, with particular focus on the role the glutathione system in this process. 4-HNE is implicated in regulation of cell growth, proliferation, differentiation, and apoptosis. 4-HNE and metabolic products of other antioxidants (carotenoids) resemble each other in chemical nature of the product and influence general pathways of signal transduction. Manifestation of 4-HNE toxicity under oxidative stress conditions is regarded as a link to many diseases whose pathogenesis is connected with modifications of proteins and nucleic acids.
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| http://dx.doi.org/10.1134/s0006297910090014 | DOI Listing |
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