This paper presents the Visual Attention Engine (VAE), which is a digital cellular neural network (CNN) that executes the VA algorithm to speed up object-recognition. The proposed time-multiplexed processing element (TMPE) CNN topology achieves high performance and small area by integrating 4800 (80 × 60) cells and 120 PEs. Pipelined operation of the PEs and single-cycle global shift capability of the cells result in a high PE utilization ratio of 93%. The cells are implemented by 6T static random access memory-based register files and dynamic shift registers to enable a small area of 4.5 mm(2). The bus connections between PEs and cells are optimized to minimize power consumption. The VAE is integrated within an object-recognition system-on-chip (SoC) fabricated in the 0.13- μm complementary metal-oxide-semiconductor process. It achieves 24 GOPS peak performance and 22 GOPS sustained performance at 200 MHz enabling one CNN iteration on an 80 × 60 pixel image to be completed in just 4.3 μs. With VA enabled using the VAE, the workload of the object-recognition SoC is significantly reduced, resulting in 83% higher frame rate while consuming 45% less energy per frame without degradation of recognition accuracy.
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http://dx.doi.org/10.1109/TNN.2010.2085443 | DOI Listing |
MedComm (2020)
January 2025
Department of Urology, Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Centre for Geriatrics Shenzhen People's Hospital, The First Affiliated Hospital, Southern University of Science and Technology Shenzhen China.
Periodontitis is a chronic periodontal inflammatory disease caused by periodontal pathogens commonly seen in adults. Eupalinolide B (EB) is a sesquiterpenoid natural product extracted from Eupatorium lindleyanum and has been reported as a potential drug for cancers and immune disorders. Here, we explored the ameliorative effects and underlying molecular mechanism of EB on periodontitis for the first time.
View Article and Find Full Text PDFiScience
January 2025
Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Successful pancreatic ductal adenocarcinoma (PDAC) immunotherapy requires therapeutic combinations that induce quality T cells. Tumor microenvironment (TME) analysis following therapeutic interventions can identify response mechanisms, informing design of effective combinations. We provide a reference single-cell dataset from tumor-infiltrating leukocytes (TILs) from a human neoadjuvant clinical trial comparing the granulocyte-macrophage colony-stimulating factor (GM-CSF)-secreting allogeneic PDAC vaccine GVAX alone, in combination with anti-PD1 or with both anti-PD1 and CD137 agonist.
View Article and Find Full Text PDFVirchows Arch
January 2025
Institute of Pathology, University Medical Center Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.
Penile cancer (PeCa) is a rare disease with poor prognosis in the metastatic stage. Neither effective adjuvant nor palliative therapeutic options are available. Research efforts in this field have so far failed to establish robust predictors of survival.
View Article and Find Full Text PDFActa Pharm Sin B
December 2024
School of Pharmacy, Institute of Hepatology and Metabolic Diseases, Department of Hepatology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 311121, China.
Specific tumor-targeted gene delivery remains an unsolved therapeutic issue due to aberrant vascularization in tumor microenvironment (TME). Some bacteria exhibit spontaneous chemotaxis toward the anaerobic and immune-suppressive TME, which makes them ideal natural vehicles for cancer gene therapy. Here, we conjugated ZIF-8 metal-organic frameworks encapsulating eukaryotic murine interleukin 2 () expression plasmid onto the surface of VNP20009, an attenuated strain with well-documented anti-cancer activity, and constructed a TME-targeted delivery system named /ZIF-8@.
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January 2025
Department of Environmental Science and Engineering, School of Engineering and Sciences, SRM University-AP, Amaravati, Andhra Pradesh 522240, India.
This article evaluated different production strategies, characteristics, and applications of biochar for ameliorating soil fertility and microbial diversity. The biochar production techniques are evolving, indicating that newer methods (including hydrothermal and retort carbonization) operate with minimum temperatures, yet resulting in high yields with significant improvements in different properties, including heating value, oxygen functionality, and carbon content, compared to the traditional methods. It has been found that the temperature, feedstock type, and moisture content play critical roles in the fabrication process.
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