AI Article Synopsis
- Cytoplasmic actins interact with viral proteins and are found in virus particles, suggesting a role in viral infections.
- In an analysis of Sendai virus infection in polarized cells, significant remodeling of β-cytoplasmic actin was observed, closely linked to enhanced viral replication.
- Suppressing actin production led to decreased virus particle output, indicating that Sendai virus relies on actin remodeling to optimize its replication process, potentially differing from mechanisms used by other enveloped viruses.
Article Abstract
Cytoplasmic actins have been found interacting with viral proteins and identified in virus particles. We analyzed by confocal microscopy the cytoplasmic β- and γ-actin patterns during the course of Sendai virus infections in polarized cells. We observed a spectacular remodeling of the β-cytoplasmic actin which correlated with productive viral multiplication. Conversely, suppression of M during the course of a productive infection resulted in the decrease of particle production and the absence of β-actin remodeling. As concomitant suppression of β- and γ-actins resulted as well in reduction of virus particle production, we propose that Sendai virus specifically induces actin remodeling in order to promote efficient virion production. Beta- and γ-cytoplasmic actin recruitment could substitute for that of the endosomal sorting complex required for transport (ESCRT) mobilized by other enveloped viruses but apparently not used by Sendai virus.
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| http://dx.doi.org/10.1016/j.virol.2010.10.003 | DOI Listing |
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