Purpose: To evaluate the surgical-orthodontic stability of treating skeletal open bite patients with mandibular ramus osteotomies using a modified inverted L osteotomy (M-ILO) and counterclockwise rotation of the mandible stabilized with rigid fixation.
Patients And Methods: In a retrospective review, 12 patients with skeletal open bites (8 females, 4 males) who received mandibular M-ILO in the period 2004-2007 at Tohoku University Hospital were studied. Lateral cephalograms were taken immediately before surgery (T1), immediately after surgery (T2), and at 1 yr after surgery (T3). Cephalometric analysis for point B, pogonion, menton, and mandibular plane angle was obtained at the designated time intervals.
Results: Mandibular counterclockwise rotation showed stability for point B, pogonion, and menton referred to X-Y coordinate, and for mandibular plane angle. The mean value for each variable was compared between T2 and T3. No statistically significant change was observed for all variables.
Conclusions: With a well-positioned maxilla, skeletal open bite can be successfully treated using M-ILO. Mandibular counterclockwise rotation showed stability at 1 yr after surgery.
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http://dx.doi.org/10.1016/j.joms.2010.05.020 | DOI Listing |
Achondroplasia, the most prevalent short-stature disorder, is caused by missense variants overactivating the fibroblast growth factor receptor 3 (FGFR3). As current surgical and pharmaceutical treatments only partially improve some disease features, we sought to explore a genetic approach. We show that an enhancer located 29 kb upstream of mouse Fgfr3 (-29E) is sufficient to confer a transgenic mouse reporter with a domain of expression in cartilage matching that of Fgfr3.
View Article and Find Full Text PDFOpen Access J Sports Med
January 2025
Prodia Clinical Laboratory, Jakarta, Indonesia.
Background: Sarcopenia is characterized by the progressive loss of skeletal muscle mass and poses a significant health challenge for older adults by increasing the risk of disability and decreasing quality of life. Yoga considers as a low-risk and beneficial exercise for older adults. This research aims to evaluate the potential of yoga practice as a preventive strategy against sarcopenia in Indonesian older adults.
View Article and Find Full Text PDFBMC Geriatr
January 2025
Geroscience Research Center, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, 474-8511, Japan.
Background: To investigate whether continuous intervention using soymilk containing high soy protein improves physical frailty, a randomized controlled trial was conducted among the Japanese pre-frail and frail elderly.
Methods: Japanese pre-frail and frail elderly participants (n = 73) were randomly assigned to the high-soy protein and control groups, who then ingested soymilk containing 14.5 g/200 ml and 3.
PLoS One
January 2025
Mandel Center for Heart and Vascular Research, The Duke Cardiovascular Research Center, Duke University Medical Center, Durham, NC, United States of America.
Early events in the reprogramming of fibroblasts to cardiac muscle cells are unclear. While various histone undergo modification and re-positioning, and these correlate with the activity of certain genes, it is unknown if these events are causal or happen in response to reprogramming. Histone modification and re-positioning would be expected to open up chromatin on lineage-specific genes and this can be ascertained by studying nucleosome architecture.
View Article and Find Full Text PDFJ Clin Endocrinol Metab
January 2025
Division of Orthogenetics, Department of Pediatrics, Nemours Children's Hospital, Delaware, 1600 Rockland Road, Wilmington, DE, 19803, USA.
Achondroplasia is the most common disproportionate short-stature skeletal dysplasia. Features associated with achondroplasia are rhizomelia, macrocephaly, midface hypoplasia, and typical cognition. Potential medical complications include foramen magnum stenosis, hydrocephalus, middle ear dysfunction, obstructive and central sleep apnea, spinal stenosis and genu varum.
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