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Pharmacogenetic Testing in Admixed Populations: Frequency of the AMR PGx Working Group Tier 1 Variant Alleles in Brazilians.
J Mol Diagn
January 2025
Clinical Research and Technological Development Division (Divisão de Pesquisa Clínica e Desenvolvimento Tecnológico), Brazilian National Cancer Institute (Instituto Nacional de Câncer), Rio de Janeiro, Brazil. Electronic address:
This article examines the frequency distribution of Tier 1 pharmacogenetic variants of the Association for Molecular Pathology Pharmacogenomics Working Group Recommendations in two large (>1.000 individuals) cohorts of the admixed Brazilian population, and in patients from the Brazilian Public Health System enrolled in pharmacogenetic trials. Three Tier 1 variants, all in DPYD, were consistently absent, which may justify their non-inclusion in genotyping panels for Brazilians; 13 variants had frequency < 1.
View Article and Find Full Text PDFLong-term human influence on the demography and genetic diversity of the hyperdominant Bertholletia excelsa in the Amazon Basin.
Curr Biol
January 2025
Department of Coevolution of Land Use and Urbanisation, Max Planck Institute of Geoanthropology, 07745 Jena, Germany; Department of Archaeology, Max Planck Institute of Geoanthropology, 07745 Jena, Germany; School of Archaeology, University of the Philippines, Quezon City 1101, the Philippines. Electronic address:
The Amazon rainforest is characterized by a limited number of hyperdominant trees that play an oversized role in its ecosystems, nutrient cycle, and rainfall production. Some of these, such as the Brazil nut, appear to have been intensively exploited and dispersed by Indigenous populations since their earliest arrival in this part of South America around 13,000 years ago. However, the genetic diversity-and geographic structure-of these species remains poorly understood, as does their exact relationship with past human land use.
View Article and Find Full Text PDF"When People Reach Out that is When They're Desperate": Understanding Informal and Formal Help-Seeking Practices for Gambling among Aboriginal Peoples in the Northern Territory, Australia.
J Gambl Stud
January 2025
Flinders Health and Medical Research Institute, Rural and Remote Health, Flinders University, Charles Darwin University, PO Box U362 PO Box 42500, Casuarina, NT, 0815, Australia.
This study provides an in-depth qualitative exploration of Aboriginal peoples' experiences with seeking help for gambling-related issues in the Northern Territory (NT), Australia. Through semi-structured interviews with 29 participants, including regular and occasional gamblers as well as those affected by others' gambling, the research highlights key barriers to seeking formal help. These barriers included the normalisation of gambling within Aboriginal communities, denial of gambling problems, feelings of shame, privacy concerns, and a lack of trust in mainstream services.
View Article and Find Full Text PDFA Survey of Wild Indigenous Orchid Populations in Western Australia Reveals Spillover of Exotic Viruses.
Viruses
January 2025
School of Medical, Molecular and Forensic Sciences, College of Environmental and Life Sciences, Murdoch University, 90 South Street, Perth 6150, Australia.
is a terrestrial orchid endemic to southwestern Australia. The virus status of has not been studied. Eighty-three samples from 16 populations were collected, and sequencing was used to identify RNA viruses from them.
View Article and Find Full Text PDFFarming of Indigenous Crayfish in Russia: A Mini-Review of Recent Studies.
Animals (Basel)
January 2025
Murmansk Marine Biological Institute of the Russian Academy of Sciences (MMBI RAS), 183038 Murmansk, Russia.
Natural populations of crayfish in Europe have experienced significant declines due to the spread of crayfish plague, overfishing, competition with invasive crayfish species, and habitat degradation. Consequently, crayfish farming has gained importance in meeting the increasing demand for crayfish products. Although Russia boasts abundant water resources, the development of crayfish aquaculture remains nascent.
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