AI Article Synopsis
- NrpR is a transcription factor in archaea that senses levels of 2-oxoglutarate (2OG) and regulates nitrogen acquisition genes accordingly.
- When 2OG levels are low, NrpR inhibits the expression of these nitrogen-related genes.
- Research by Wisedchaisri et al. (2010) revealed the specific region where 2OG binds to NrpR and showed that the binding sites are conserved among similar proteins.
Article Abstract
NrpR is a 2-oxoglutarate (2OG)-sensing transcription factor found in the archaeal phylum euryarchaetoa. When 2OG concentrations are low, NrpR transcriptionally represses expression of the nitrogen acquisition genes. Structural studies by Wisedchaisri et al. (2010) have identified the cleft region, where 2OG binds to NrpR. Their study has highlighted conservation of 2OG-binding residues among other 2OG-responsive proteins.
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| http://dx.doi.org/10.1016/j.str.2010.10.003 | DOI Listing |
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