AI Article Synopsis
- Marek's disease (MD) is caused by Marek's disease virus (MDV), which leads to immunosuppression and tumor formation in chickens.
- Despite effective vaccines and genetically resistant chicken lines, the exact mechanisms of how MDV interacts with its host remain largely unknown.
- Recent advancements in gene and protein profiling techniques are helping researchers uncover the pathogenesis of MDV, host immunoresponses, and the genetic factors affecting resistance to the disease, including the use of microRNA and RNA interference technologies.
Article Abstract
Marek's disease (MD) is an immunosuppressive and proliferative disease of domestic chickens caused by a highly oncogenic cell-associated alpha-herpesvirus, named Marek's disease virus (MDV). Despite the availability of highly efficacious vaccines for control of MD and existence of lines of chickens which display differential genetic susceptibility or resistance to this disease, little is known about the underlying mechanisms of MDV-host interactions. The recent advent of global or targeted gene and protein expression profiling has paved the way towards gaining a better understanding of host responses to MDV. The main objective of this review is to discuss some of the recent advancements made in relation to elucidating the mechanisms of MDV pathogenesis, host responses to MDV, genetic resistance/susceptibility to MD, and immunity conferred by vaccines. In this regard, particular emphasis has been placed on studies employing proteome and transcriptome profiling approaches. Finally, the utility of microRNA and RNA interference (RNAi) technologies for functional analysis of genes, proteins, and pathways that play a role in the complex interactions between MDV and its host is discussed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.vetimm.2010.10.007 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Increasing microplastic concentrations have nonlinear impacts on the physiology of reef-building corals.
Sci Total Environ
January 2025
Department of Animal Ecology & Systematics, Justus Liebig University, Giessen, Germany; Hawai'i Institute of Marine Biology, University of Hawai'i at Mānoa, Kāne'ohe, HI, USA.
The pollution of marine environments with plastics, particularly microplastic (MP, i.e., plastic particles <5 mm), is a major threat to marine biota, including corals.
View Article and Find Full Text PDFGranulocyte macrophage colony stimulating factor in virus-host interactions and its implication for immunotherapy.
Cytokine Growth Factor Rev
December 2024
Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3N6, Canada. Electronic address:
Viruses have evolved to strategically exploit cellular signaling pathways to evade host immune defenses. GM-CSF signaling plays a pivotal role in regulating inflammation, activating myeloid cells, and enhancing the immune response to infections. Due to its central role in the immune system, viruses may target this pathway to further establish infection.
View Article and Find Full Text PDFFunctional characterization and regulatory pattern of Neoseiulus barkeri peptidoglycan recognition protein (PGRP).
Int J Biol Macromol
January 2025
Key Laboratory of Agricultural Biosafety and Green Production of Upper Yangtze River, Key Laboratory of Entomology and Pest Control Engineering, College of Plant Protection, Southwest University, Chongqing 400716, China; Yibin Academy of Southwest University, Yibin 644000, China. Electronic address:
Compared with traditional biological control, the co-use of entomopathogenic fungi and multiple enemies has made great progress in biocontrol technology. However, the risk posed by entomopathogenic fungi to their host has not been fully evaluated. Further, the interaction between them has not described adequately.
View Article and Find Full Text PDFBacillus coagulans alleviates intestinal barrier injury induced by Klebsiella pneumoniae in rabbits by regulating the TLR4/MyD88/NF-κB signalling pathway.
Vet Microbiol
December 2024
College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan 471000, China. Electronic address:
Probiotics effectively alleviate host diarrhoea, but the specific mechanism is not clear. Therefore, we explored the protective mechanism of Bacillus coagulans (BC) on intestinal barrier injury induced by Klebsiella pneumoniae (K. pneumoniae) in rabbits by HE, immunofluorescence and 16S rRNA.
View Article and Find Full Text PDFRole of Interferon Regulatory Factor 1 in acute and chronic virus infections.
Virology
December 2024
Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address:
Decades of research have defined the function of interferon regulatory factors (IRFs) in the antiviral immune response. Interferon regulatory factor-1 (IRF-1) is the founding member of the IRF family, with recognized antiviral effects across diverse virus infections. While most antiviral activities of IRF-1 were defined in vitro, fewer studies examined the role of IRF-1 during viral infection of an intact host.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!