AI Article Synopsis
- LE-PAD can occur in individuals without traditional cardiovascular disease risk factors, highlighting its prevalence and importance.
- In a study of 6814 participants, 1932 were found to have no risk factors, with 9% showing a low ankle-brachial index (ABI) and 7.8% a high ABI.
- The findings suggest that low ABI is linked to the presence of coronary artery disease, indicating that even in low-risk groups, LE-PAD is significant and warrants attention.
Article Abstract
Objective: Lower-extremity peripheral artery disease (LE-PAD), is strongly related to traditional risk factors (smoking, hypertension, dyslipidemia, diabetes). We hypothesized that the prevalence of LE-PAD in the absence of traditional CVD risk factors is not negligible, and that this condition would remain associated with subclinical atherosclerosis in other territories.
Methods: In the Multi-Ethnic Study of Atherosclerosis, we classified participants without any traditional risk factor according to their ankle-brachial index (ABI) into 3 groups: low (<1.00), normal (1.00-1.30) and high (>1.30) ABI. Coronary or carotid artery diseases were defined by the presence of any coronary artery calcification (CAC score>0) or carotid plaque, respectively.
Results: Among the 6814 participants, 1932 had no traditional risk factors. A low- and high ABI were found in 176 (9%) and 149 (7.8%) cases, respectively. Lower glomerular filtration rate (OR: 0.88/10 units, p=0.04) and higher Interleukin-6 levels (OR: 1.42/natural-log unit, p=0.02) were associated with low ABI. Past smoking (cessation>10 years) and pulse pressure had borderline association with low ABI. In adjusted models, low-ABI was significantly associated with CAC prevalence (OR: 1.22, p<0.03). No significant association was found with carotid plaque.
Conclusion: In the absence of traditional CVD risk factors, LE-PAD is still common and associated with coronary artery disease.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415364 | PMC |
| http://dx.doi.org/10.1016/j.atherosclerosis.2010.10.011 | DOI Listing |
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