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Seascape Genomics of the Smooth Hammerhead Shark Reveals Regional Adaptive Clinal Variation.
Ecol Evol
December 2024
Molecular Breeding and Biodiversity Group, Department of Genetics Stellenbosch University Stellenbosch South Africa.
Globally, hammerhead sharks have experienced severe declines owing to continued overexploitation and anthropogenic change. The smooth hammerhead shark remains understudied compared to other members of the family Sphyrnidae. Despite its vulnerable status, a comprehensive understanding of its genetic landscape remains lacking in many regions worldwide.
View Article and Find Full Text PDFCare trajectories around a first dementia diagnosis in patients with serious mental illness.
Geriatr Gerontol Int
June 2024
Department of Family Medicine, Faculty of Medicine and Health Sciences, McGill University, Montréal, Québec, Canada.
Aim: To develop a typology of care trajectories (CTs) 1 year before and after a first dementia diagnosis in individuals aged ≥65 years, with prevalent schizophrenia or bipolar disorder.
Methods: This was a longitudinal, retrospective cohort study using health administrative data (1996-2016) from Quebec (Canada). We selected patients aged ≥65 years with an incident diagnosis of dementia between 1 January 2014 and 31 December 2016, and a diagnosis of schizophrenia and/or or bipolar disorder.
CRISPR/Cas9 mutagenesis of the GROWTH-REGULATING FACTOR (GRF) gene family.
Front Genome Ed
October 2023
Department of Plant Biology, University of Georgia, Athens, GA, United States.
Genome editing in plants typically relies on T-DNA plasmids that are mobilized by -mediated transformation to deliver the CRISPR/Cas machinery. Here, we introduce a series of CRISPR/Cas9 T-DNA vectors for minimal settings, such as teaching labs. Gene-specific targeting sequences can be inserted as annealed short oligonucleotides in a single straightforward cloning step.
View Article and Find Full Text PDFSmart sensing flexible sutures for glucose monitoring in house sparrows.
Analyst
November 2023
Department of Chemical and Biological Engineering, Tufts University, Medford, MA, 02155, USA.
There is a need for flexible chemical sensors for the ecological and physiological research of avian species such as house sparrows (). Current methods in this field are invasive and require multiple physical interactions with the birds. Emerging research in flexible bioelectronics can enable realization of implantable devices that are mechanically compliant with the underlying tissues for continuous real-time sensing .
View Article and Find Full Text PDFWhole blood methylome-derived features to discriminate endocrine hypertension.
Clin Epigenetics
November 2022
Université Paris Cité, CNRS, INSERM, Institut Cochin, F-75014, Paris, France.
Article Synopsis
- Arterial hypertension is a major global health issue and can be either primary or secondary, with secondary cases linked to specific endocrine disorders like Cushing's syndrome, primary aldosteronism, and pheochromocytoma.
- Effective diagnosis of endocrine hypertension relies on hormone tests, but identifying unique blood DNA methylation patterns could enhance diagnosis and treatment strategies.
- The study examined DNA methylation patterns in 255 patients, successfully distinguishing between primary and secondary hypertension using machine learning techniques, with varying levels of accuracy in predictive models.
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