AI Article Synopsis
- - The study analyzed 26 stocks of the Chagas disease parasite, Trypanosoma cruzi, alongside 2 related stocks, examining the relationship between genetic diversity and protein expression using advanced proteomic techniques.
- - A strong correlation was found between genetic distance and differences in protein expression, indicating that phylogenetic variations correlate with how these parasites express specific proteins.
- - The findings suggest potential new avenues for vaccine and drug development, as well as the identification of unique biomarkers for different strains of T. cruzi, enhancing our understanding of this human pathogen.
Article Abstract
We performed a phylogenetic character mapping on 26 stocks of Trypanosoma cruzi, the parasite responsible for Chagas disease, and 2 stocks of the sister taxon T. cruzi marinkellei to test for possible associations between T. cruzi-subspecific phylogenetic diversity and levels of protein expression, as examined by proteomic analysis and mass spectrometry. We observed a high level of correlation (P < 10(-4)) between genetic distance, as established by multilocus enzyme electrophoresis, and proteomic dissimilarities estimated by proteomic Euclidian distances. Several proteins were found to be specifically associated to T. cruzi phylogenetic subdivisions (discrete typing units). This study explores the previously uncharacterized links between infraspecific phylogenetic diversity and gene expression in a human pathogen. It opens the way to searching for new vaccine and drug targets and for identification of specific biomarkers at the subspecific level of pathogens.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996636 | PMC |
| http://dx.doi.org/10.1073/pnas.1015496107 | DOI Listing |
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