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Advanced sleep phase syndrome: Role of genetics and aging.
Handb Clin Neurol
January 2025
Sleep Medicine Center, Department of Neurology, Villa Serena Hospital, Città S. Angelo, Pescara, Italy; Villaserena Research Foundation, Città S. Angelo, Pescara, Italy.
Advanced sleep phase (ASP) is seldom brought to medical attention because many individuals easily adapt to their early chronotype, especially if it emerges before the age of 30 and is present in a first-degree relative. In this case, the disorder is considered familial (FASP) and is mostly discovered coincidentally in the presence of other sleep disorders, mainly obstructive sleep apnea syndrome (OSAS). The prevalence of FASP is currently estimated to be between 0.
View Article and Find Full Text PDFForty years of seasonal affective disorder.
Psychiatr Pol
October 2024
Uniwersytet Medyczny w Poznaniu.
In 2024, we observe the fortieth anniversary of the publication, where, for the first time, the term of Seasonal Affective Disorder (SAD) was used. Presently, SAD is regarded as a special category of mood disorder. In the American Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-V), the seasonality makes a specifier, "with seasonal pattern", both for recurrent depression or Major Depressive Disorder (MDD), and for Bipolar Disorder (BD).
View Article and Find Full Text PDFMelatonin protects aged oocytes from depalmitoylation-mediated quality reduction by promoting PPT1 degradation and antioxidation.
Redox Biol
January 2025
Department of Reproductive Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, 210002, China; State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, Jiangsu, 211166, China; Department of Reproductive Medicine, Affiliated Jinling Hospital, The First School of Clinical Medicine, Southern Medical University, Nanjing, 210002, China. Electronic address:
Oocyte aging is closely related to a decline in female fertility, accompanied by increased reactive oxygen species levels and changes in protein posttranslational modifications. However, the role of protein palmitoylation in oocyte aging has not been investigated. In the present study, a new association between redox and palmitoylation in aging oocytes was found.
View Article and Find Full Text PDFNeuroprotective Effect of Melatonin Loaded in Human Serum Albumin Nanoparticles Applied Subconjunctivally in a Retinal Degeneration Animal Model.
Pharmaceutics
January 2025
Unidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA), CONICET and Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba 5000, Argentina.
Background/objectives: Neurodegenerative ocular diseases, such as age-related macular degeneration (AMD) and glaucoma, represent growing public health concerns. Oxidative stress plays a key role in their development, damaging retinal cells and accelerating disease progression. Melatonin (Mel) is a potent antioxidant with neuroprotective properties; however, it faces limitations such as low solubility.
View Article and Find Full Text PDFMelatonin Enhances Maize Germination, Growth, and Salt Tolerance by Regulating Reactive Oxygen Species Accumulation and Antioxidant Systems.
Plants (Basel)
January 2025
College of Agriculture, Heilongjiang Bayi Agricultural University, Daqing 163319, China.
Melatonin (MT) is a crucial hormone that controls and positively regulates plant growth under abiotic stress, but the biochemical and physiological processes of the combination of melatonin seed initiation and exogenous spray treatments and their effects on maize germination and seedling salt tolerance are not well understood. Consequently, in this research, we utilized the maize cultivars Zhengdan 958 (ZD958) and Demeiya 1 (DMY1), which are extensively marketed in northeastern China's high-latitude cold regions, to reveal the modulating effects of melatonin on maize salinity tolerance by determining the impacts of varying concentrations of melatonin on maize seedling growth characteristics, osmoregulation, antioxidant systems, and gene expression. The findings revealed that salt stress (100 mM NaCl) significantly inhibited maize seed germination and seedling development, which resulted in significant increases in the HO and O content and decreases in the antioxidant enzyme activity and photosynthetic pigment content in maize seedlings.
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