AI Article Synopsis
- Researchers are exploring localized magnetic hyperthermia as a cancer treatment, focusing on targeted delivery to tumor sites.
- The study used neural progenitor cells (NPCs) as delivery vehicles for iron-based magnetic nanoparticles (MNPs) in a mouse melanoma model, showing efficient loading without harming the cells.
- After exposing the tumor to alternating current magnetic fields, the NPCs delivered MNPs effectively, resulting in significant tumor regression within 24 hours after treatment.
Article Abstract
Localized magnetic hyperthermia as a treatment modality for cancer has generated renewed interest, particularly if it can be targeted to the tumor site. We examined whether tumor-tropic neural progenitor cells (NPCs) could be utilized as cell delivery vehicles for achieving preferential accumulation of core/shell iron/iron oxide magnetic nanoparticles (MNPs) within a mouse model of melanoma. We developed aminosiloxane-porphyrin functionalized MNPs, evaluated cell viability and loading efficiency, and transplanted neural progenitor cells loaded with this cargo into mice with melanoma. NPCs were efficiently loaded with core/shell Fe/Fe(3)O(4) MNPs with minimal cytotoxicity; the MNPs accumulated as aggregates in the cytosol. The NPCs loaded with MNPs could travel to subcutaneous melanomas, and after A/C (alternating current) magnetic field (AMF) exposure, the targeted delivery of MNPs by the cells resulted in a measurable regression of the tumors. The tumor attenuation was significant (p < 0.05) a short time (24 h) after the last of three AMF exposures.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011034 | PMC |
| http://dx.doi.org/10.1021/nn100870z | DOI Listing |
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