Investigation of the bioactive crude extracts from two populations of the red alga Laurencia dendroidea from the southeastern Brazilian coast led to the identification of five sesquiterpenes: (+)-obtusane (1), a triquinane derivative (2), (-)-elatol (3), obtusol (4), and cartilagineol (5). An antileishmanial bioassay against Leishmania amazonensis was conducted for crude lipophilic extracts and for sesquiterpenes 2, 3, and 4. Compounds 3 and 4 displayed in vitro and in vivo leishmanicidal activity and very low cytotoxicity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1055/s-0030-1250526 | DOI Listing |
Publication Analysis
Top Keywords
red alga
8
alga laurencia
8
laurencia dendroidea
8
antileishmanial sesquiterpenes
4
sesquiterpenes brazilian
4
brazilian red
4
dendroidea investigation
4
investigation bioactive
4
bioactive crude
4
crude extracts
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!