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Insect Arylalkylamine -Acyltransferases: Mechanism and Role in Fatty Acid Amide Biosynthesis.
Front Mol Biosci
July 2018
Department of Chemistry, University of South Florida, Tampa, FL, United States.
Arylalkylamine -acyltransferases (AANATs) catalyze the formation of an -acylamide from an acyl-CoA thioester and an amine. One well known example is the production of -acetylserotonin from acetyl-CoA and serotonin, a reaction in the melatonin biosynthetic pathway from tryptophan. AANATs have been identified from a variety of vertebrates and invertebrates.
View Article and Find Full Text PDFInduced melanin reduces mutations and cell killing in mouse melanoma.
Photochem Photobiol
March 1997
Department of Radiology, UMDNJ-New Jersey Medical School, Newark 07103, USA.
When melanin absorbs light energy, it can produce potentially damaging active oxygen species. There is little doubt that constitutive pigment in dark-skinned individuals is photoprotective against skin cancer, but induced pigment-as in tanning-may not be. The first step in cancer induction is mutation in DNA.
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