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http://dx.doi.org/10.1097/PCC.0b013e3181d9c6e9 | DOI Listing |
J Comp Eff Res
January 2025
Mitsubishi Tanabe Pharma America, Inc., Health Economics and Outcomes Research (HEOR), Medical Affairs, Jersey City, NJ, 07310 USA.
To estimate time-to-progression milestones in people with amyotrophic lateral sclerosis (PALS) treated versus not treated with intravenous (IV) edaravone (Radicava IV, Mitsubishi Tanabe Pharma America [MTPA], hereafter "IV edaravone") in a real-world setting. IV edaravone is US FDA approved for the treatment of ALS and was shown in clinical trials to slow the rate of physical functional decline. This retrospective observational analysis included PALS continuously enrolled in Optum's Clinformatics Data Mart between 8 August 2017 and 31 December 2021.
View Article and Find Full Text PDFFront Vet Sci
January 2025
Department of Clinical Sciences, Ross University School of Veterinary Medicine, Basseterre, Saint Kitts and Nevis.
The oxygen reserve index (ORi) is a novel, non-invasive parameter that estimates arterial oxygen partial pressure (PaO) during hyperoxia when the fraction of inspired oxygen (FiO) is elevated. This study aimed to assess the utility of the ORi/FiO ratio as an index for quantifying F-shunt, serving as an estimate of venous admixture. Anesthetic records were reviewed from 44 dogs undergoing general anesthesia and requiring arterial catheterization.
View Article and Find Full Text PDFAnn Pediatr Cardiol
December 2024
Department of Neonatology, Manipal Hospital, Bengaluru, Karnataka, India.
Background And Objective: Respiratory distress is the most common cause requiring neonatal intensive care unit admission. As respiratory and cardiac functions are closely interrelated, some cardiac dysfunction is expected in respiratory distress. The myocardial performance index (MPI) is an index to assess global myocardial function, easily measurable by bedside echocardiography and reliable.
View Article and Find Full Text PDFMed Intensiva (Engl Ed)
January 2025
Intensive Care Unit, Hospital Universitario Doctor Peset, Av Gaspar Aguilar 90, 46017 Valencia, Spain.
Objective: We aimed to determine predictors of non-invasive ventilation (NIV) failure and validate a nomogram to identify patients at risk of NIV failure.
Design: Observational, analytical study of a retrospective cohort from a single center, compared with an external cohort (March 2020 to August 2021).
Setting: Two intensive care units (ICUs).
Expert Rev Respir Med
January 2025
Department of Anesthesia and Intensive Care, Fondazione Istituto "G. Giglio" Cefalù, Cefalù, Italy.
Introduction: To evaluate the effectiveness of noninvasive positive pressure ventilation (NPPV) versus standard therapy in severe asthma exacerbations through meta-analysis.
Methods: Nine randomized controlled trials (344 patients) were analyzed from inception to August 2024. Primary outcomes included respiratory rate, forced expiratory volume in first second (FEV1), and oxygen saturation (SpO2).
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