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MicroRNAs secreted by the parasitic nematode Brugia malayi disrupt lymphatic endothelial cell integrity.
PLoS Negl Trop Dis
December 2024
Systems Genomics Section, Laboratory of Parasitic Diseases, Division of Intramural Research, NIAID, NIH, Bethesda, Maryland, United States of America.
Lymphatic filariasis (LF) is a neglected tropical disease affecting over 51 million people in 72 endemic countries. Causative agents of LF are mosquito-borne parasitic nematodes Wuchereria bancrofti, Brugia malayi, and Brugia timori. The adult parasites impact the integrity of lymphatic vessels and damage valves, leading to a remodeling of the lymphatic system and lymphatic dilation.
View Article and Find Full Text PDFIncidental diagnosis of subcutaneous filariasis with an unusual presentation in a non-endemic area-Need to worry?
J Family Med Prim Care
November 2024
Department of Pathology, Government Doon Medical College, Dehradun, Uttarakhand, India.
We report an interesting case of Bancroftian filariasis diagnosed on fine needle aspiration cytology in a young female hailing from a non-endemic hilly area of India, who presented with a subcutaneous swelling on the left forearm. This is an unusual extra-lymphatic site to harbor filarial infestation and the cytology smears showed adult worms, eggs, and microfilariae of .
View Article and Find Full Text PDFReassessing the Significance of Mycobacterium in Neglected Tropical Diseases: A Study Protocol in Nigeria.
Int J Mycobacteriol
October 2024
Programme Department, RedAid, Enugu, Enugu State, Nigeria.
Background: Neglected tropical diseases (NTDs) significantly impact the physical and mental well-being of affected individuals, particularly in Nigeria. This study aims to evaluate the effectiveness of integrating mental health services with self-care practices for individuals suffering from leprosy, Buruli ulcer (BU), and lymphatic filariasis (LF). The role of trained Healthcare Workers (HCWs) and NTD champions (NTD-Cs) will be explored to enhance health outcomes in this population.
View Article and Find Full Text PDFDetection of Dirofilaria immitis in golden jackals (Canis aureus L.) but not in red foxes (Vulpes vulpes L.) and European badgers (Meles meles L.) in Croatia.
Parasit Vectors
November 2024
Department for Bacteriology and Parasitology, Croatian Veterinary Institute, Savska cesta 143, 10000, Zagreb, Croatia.
Article Synopsis
- Dirofilariosis is a parasite disease caused by Dirofilaria species, mainly affecting wild carnivores and raising concerns about animal health and potential transmission to domestic dogs and humans.
- In a study in Croatia, researchers examined wild carnivores, finding D. immitis in 6.5% of golden jackals, but none in red foxes or European badgers.
- Infected jackals showed varying parasite loads and possible health impacts, highlighting the need for further research on their role as potential infection reservoirs for other species.
Approaching onchocerciasis elimination in Equatorial Guinea: Near zero transmission and public health implication.
Infect Dis Poverty
November 2024
National Centre for Tropical Medicine, Institute of Health Carlos III (ISCIII in Spanish), Madrid, Spain.
Article Synopsis
- Onchocerciasis and lymphatic filariasis (LF) are diseases prevalent in Equatorial Guinea, with efforts historically focused on Bioko Island, which has successfully interrupted onchocerciasis transmission, prompting a need to assess mainland regions where transmission status is unclear.
- The study, conducted from September to December 2019, employed various diagnostic methods on a sample of 3,951 individuals to estimate the prevalence of these diseases on the mainland, marking the first cross-sectional analysis for this area.
- Results showed a very low onchocerciasis seroprevalence of 0.3%, and while no O. volvulus microfilariae were found in biopsies, DNA evidence confirmed its presence in one
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