AI Article Synopsis
- The study identifies and characterizes a gene called dmc1, which is involved in meiotic recombination, in three species of Pneumocystis, a fungus that causes pneumonia in immunosuppressed patients.
- Dmc1 is a single-copy gene that produces a protein showing 61%-70% similarity to yeast Dmc1 proteins and is mainly expressed in the cyst form of Pneumocystis.
- The analysis of the Pneumocystis jirovecii genome suggests that sexual reproduction may occur in its life cycle, marked by multiple recombination events, despite the organism being primarily haploid.
Article Abstract
The life cycle of Pneumocystis, which causes life-threatening pneumonia in immunosuppressed patients, remains poorly defined. In the present study, we have identified and characterized an orthologue of dmc1, a gene specific for meiotic recombination in yeast, in 3 species of Pneumocystis. dmc1 is a single-copy gene that is transcribed as ∼1.2-kb messenger RNA, which encodes a protein of 336-337 amino acids. Pneumocystis Dmc1 was 61%-70% identical to those from yeast. Confocal microscopy results indicated that the expression of Dmc1 is primarily confined to the cyst form of Pneumocystis. By sequence analysis of 2 single-copy regions of the human Pneumocystis jirovecii genome, we can infer multiple recombination events, which are consistent with meiotic recombination in this primarily haploid organism. Taken together, these studies support the occurrence of a sexual phase in the life cycle of Pneumocystis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058675 | PMC |
| http://dx.doi.org/10.1086/657414 | DOI Listing |
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