AI Article Synopsis
- - The natural product essramycin was synthesized using a two-step reaction without protective groups and involved a 3-amino-1,2,4-triazole intermediate.
- - The synthetic version of essramycin had its structure clearly identified.
- - Unlike the natural product, the synthetic essramycin showed no antibacterial activity.
Article Abstract
The triazolopyrimidine natural product essramycin (1) was synthesized without the use of protecting groups via a two-step reaction scheme involving a 3-amino-1,2,4-triazole intermediate, and its structure was unequivocally determined. However, in contrast to the natural product, the synthetic essramycin (1) did not display any antibacterial activity.
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| http://dx.doi.org/10.1021/np100648q | DOI Listing |
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