Objective: To explore the pharmacokinetic of Sinomenine transdermal patch.
Methods: The plasma drug concentration of Beagle dogs was determined after administration with HPLC-UVD as analysis tools. The pharmacokinetics parameters were fitted with kinetica software package.
Results: The exclusive analysis method was established with the following pharmacokinetics parameters: T (peak) = 8 h, Cmax = 366 ng/mL, MRT = 13 h. The pharmacokinetic characteristics was accordance with one-order rate and two-compartment model.
Conclusion: The method is preferable to be applied to the pharmacokinetics research and further applied pharmacological study which will play a reference role in clinical application.
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School of Pharmacy, Anhui University of Chinese Medicine, Hefei, China.
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Xiangya International Academy of Translational Medicine, Central South University, Changsha 410013, China.
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View Article and Find Full Text PDF[Preparation and characterization of near-infrared responsive sinomenine hydrochloride reservoir microneedles].
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View Article and Find Full Text PDFHexagonal liquid crystalline system containing cinnamaldehyde for enhancement of skin permeation of sinomenine hydrochloride.
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School of Pharmacy, Anhui University of Chinese Medicine, Hefei, China.
Sinomenine hydrochloride (SH) is usually applied to treat rheumatoid arthritis (RA) with severe side effects due to oral administration. Cinnamaldehyde (CA) as essential oil possesses an anti-RA effect and can facilitate transdermal penetration. Hence, this study developed hexagonal liquid crystalline (HII) gels to deliver two components (SH and CA) across the skins.
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