Little is known about how the size of an adult animal is determined and regulated. To investigate this issue in hydra, we altered the body size by surgically removing a part of the body column and/or by axial grafting, and examined changes of column length with time. When the body column was shortened it elongated and resumed the original length within 24-48 h. This increase in the body column length was not accompanied by an increase in the number of epithelial cells in the body column. Instead, each of the epithelial cells elongated longitudinally, leading to elongation of the body column. When the body column surpassed the original length, the column shortened over time. This was not accompanied by a decrease in cell number but by the shortening and thickening of the epithelial cells. TEM analysis showed that formation of microtubule arrays takes place longitudinally along the body axis in elongated cells and perpendicular to the axis in shortened cells. Treatment with a drug that degrades microtubules completely blocked changes in body length. These observations suggest that microtubules are involved in regulating the length of the hydra body column by altering the shape of the epithelial cells. We propose from these observations that hydra has a mechanism for detecting the metrical distance between the two ends of the body column.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ydbio.2010.10.035 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Granulocyte and Monocyte Adsorption Therapy in Patients With Sepsis: A Feasibility Study.
Artif Organs
January 2025
Laboratory for Immune Response and Regulatory Medicine, Fujita Health University School of Medicine, Toyoake, Japan.
Background: The pathogenesis of sepsis is thought to be linked to a dysregulated immune response, particularly that involving neutrophils. We have developed a granulocyte adsorption column as a "decoy organ," which relocates the massive inflammation in organs in the body to a blood purification column. This study was conducted to assess the safety and experimental effectiveness of granulocyte monocyte adsorption apheresis-direct hemoperfusion (G1-DHP) in the treatment of patients with sepsis, using a prospective, multicenter design.
View Article and Find Full Text PDFVenoarterial extracorporeal membrane oxygenation using magnetic levitation centrifugal pumps for fulminant myocarditis in infants, children and young adults.
Transl Pediatr
December 2024
Division of Cardiac Surgery, Department of Surgery, Dentistry, Pediatrics and Gynecology, Verona, Italy.
Background: Fulminant myocarditis (FM) is a potentially lethal disease with a wide spectrum of clinical presentation, thus making the diagnosis hard to depict. In cases where acute circulatory failure occurs venoarterial (VA) extracorporeal membrane oxygenation (ECMO) support is a valid management strategy, especially in the pediatric and adult patients. This study aims to report the results of VA ECMO for FM in our Institution.
View Article and Find Full Text PDFSilicate-Confined Hydrogen on Nanoscale Zerovalent Iron for Efficient Defluorination Reactions.
J Am Chem Soc
January 2025
School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Defluorination reactions are increasingly vital due to the extensive use of organofluorine compounds with robust carbon-fluorine (C-F) bonds; particularly, the efficient defluorination of widespread and persistent per- and polyfluoroalkyl substances under mild conditions is crucial due to their accumulation in the environment and human body. Herein, we demonstrate that surface-modified silicate of pronounced proton affinity can confine active hydrogen (•H) onto nanoscale zerovalent iron (nZVI) by withdrawing electrons from nZVI to react with bound protons, generating confined active hydrogen (•H) for efficient defluorination under ambient conditions. The exposed silicon cation (Si) of silicate functions as a Lewis acid site to activate the C-F bond by forming Si.
View Article and Find Full Text PDFDistribution of spinal damage in patients with axial spondyloarthritis as assessed by MRI: a prospective and blinded study.
Arthritis Res Ther
January 2025
Division of Rheumatology and Immunology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, Graz, 8036, Austria.
Background: Axial spondyloarthritis (SpA) leads to structural bone lesions in every part of the vertebral column. These lesions are only partially visualized on conventional radiographs, omitting posterior parts of the vertebral column and the thoracic spine, that may nevertheless contribute to impaired spinal mobility and function in patients with axial SpA.
Methods: In this prospective and blinded investigation, we assessed the distribution of structural spinal lesions using magnetic resonance imaging (MRI) of the whole spine in 55 patients with axial SpA classified according to the Assessment in Spondyloarthritis International Society (ASAS) criteria.
The "Arrow Factor" in Gluteoplasty and Brazilian Butt Lift.
Plast Reconstr Surg Glob Open
January 2025
From the Plastic Surgery Chair, Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genova, Italy.
The gluteal region has become a rising area of interest in plastic surgery in recent years, as reflected in body contouring surgery trends. In this study, the authors explain what the arrow effect consists of and how to highlight it during a Brazilian butt lift or a gluteal liposculpture: liposuction of the sacral triangle, fat grafting of the upper gluteal quadrants, liposuction of the dimples of Venus and of the midline superficially to the spinal column, and fat grafting of the erector spinae muscles.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!