A festskrift in honor of the career contributions of Gerald E. McClearn was held in State College, Pennsylvania in May 2009. A selection of papers presented at that celebration is included in this issue of Behavior Genetics. These papers illustrate contemporary progress in research areas that have been chosen to reflect key aspects of Jerry's career accomplishments.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10519-010-9411-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Heterogeneous stocks and selective breeding in aging research.
ILAR J
July 2011
College of Health and Human Development, The Pennsylvania State University, 315 Health and Human Development East, University Park, PA 16802, USA.
There are advantages and limitations to using genetically heterogeneous stocks and selective breeding procedures in gerontological and health span research. Animal models that address complex systems of aging involve constraint or manipulation of genetic diversity. They derive from levels of genetic analysis ranging from molecular to quantitative and are relevant to levels of causal hierarchy from base sequences to complex multivariate phenotypes.
View Article and Find Full Text PDFTail tendon break time: a biomarker of aging?
J Gerontol A Biol Sci Med Sci
March 2011
Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center San Antonio, STCBM Room 3.325, 15355 Lambda Drive, San Antonio, TX 78245-3207, USA.
Research has attempted to identify biomarkers of aging that are predictive of longevity and specific age-related changes during animal life span. Tail tendon break time (TTBT), one presumed biomarker, measures collagen cross-linking, known to increase with age. Significant differences in the rate of increase of TTBT with age have been reported between mouse strains and animal species.
View Article and Find Full Text PDFQuantitative trait loci analysis of tail tendon break time in mice of C57BL/6J and DBA/2J lineage.
J Gerontol A Biol Sci Med Sci
February 2011
Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, STCBM Room 3.325, 15355 Lambda Drive, San Antonio, TX 78245-3207, USA.
Tail tendon break time (TTBT), a measure of collagen cross-linking, shown to increase with age differs significantly among inbred strains of mice, indicating underlying genetic influences. This study was aimed to identify quantitative trait loci (QTLs) associated with tail tendon break time at three ages (200, 500, and 800 days of age) for 23 BxD recombinant inbred strains of mice and B6D2F(2) mice derived from C57BL/6J and DBA/2J strains. Heritability estimates were calculated, and QTL analyses were conducted using interval-mapping methods.
View Article and Find Full Text PDFQuantitative trait loci (QTL) analysis of longevity in C57BL/6J by DBA/2J (BXD) recombinant inbred mice.
Aging Clin Exp Res
February 2010
The Biomechanics Laboratory, Department of Kinesiology, College of Health and Human Development, The Pennsylvania State University, University Park, PA, USA.
Background And Aims: Genes associated with longevity have been identified using both single gene and genome-wide approaches in a variety of species. The aim of this study was to identify quantitative trait loci (QTLs) that influence longevity in male and female mice from twenty-three C57BL/6J by DBA/2J (BXD) recombinant inbred (RI) strains.
Methods: Approximately 12 animals of each sex for each RI strain were maintained under standard conditions until natural death or moribundity criteria were met.
Genomic analysis of variation in hindlimb musculature of mice from the C57BL/6J and DBA/2J lineage.
J Hered
July 2010
School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK.
The precise locations of attachment points of muscle to bone-the origin and insertion sites-are crucial anatomical and functional characteristics that influence locomotor performance. Mechanisms that control the development of these interactions between muscle, tendon, and bone are currently not well understood. In a subset of BXD recombinant inbred (RI) strains derived from the C57BL/6J and DBA/2J strains, we observed a soleus femoral attachment anomaly (SFAA) that was rare in both parental strains (Lionikas, Glover et al.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!