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As the mobile cassette carrier of the methicillin resistance gene that is transported across staphylococci species, the evolution and origin of Staphylococcal Cassette Chromosome (SCC)-and in particular, the composition of and SCC-have been extensively discussed in the scientific literature; however, information regarding its dissemination across geographical limits and evolution over decades remains limited. In addition, whole-genome sequencing-based macro-analysis was unable to provide sufficiently detailed evolutionary information on SCC. Herein, the cassette chromosome recombinase genes , as essential components of SCC, were employed to explore the evolution of SCC.

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