Vesicular trafficking may play a crucial role in the pathogenesis and survival of the malaria parasite. ADP-ribosylation factors (ARFs) are among the major components of vesicular trafficking pathways in eukaryotes. The crystal structure of ARF1 GTPase from Plasmodium falciparum has been determined in the GDP-bound conformation at 2.5 Å resolution and is compared with the structures of mammalian ARF1s.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001640 | PMC |
| http://dx.doi.org/10.1107/S1744309110036997 | DOI Listing |
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