Kitahori, Kawata, Takamoto et al. described the effectiveness of a novel protocol for retrograde cerebral perfusion that included intermittent pressure augmentation for brain protection in a canine model. Based on their report, we applied this novel technique clinically. Although the duration of circulatory arrest with retrograde cerebral perfusion was long, the patient recovered consciousness soon after the operation and had no neurological deficit. Near-infrared oximetry showed recovery of intracranial blood oxygen saturation every time the pressure was augmented.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987928 | PMC |
http://dx.doi.org/10.1186/1749-8090-5-97 | DOI Listing |
BMJ Case Rep
January 2025
Trident Medical Center, North Charleston, South Carolina, USA.
As an emerging toxic recreational drug, kratom use has been associated with a range of adverse effects, but reports of structural changes in the central nervous system are rare. We report a case of a young man in his 20s with a history of anxiety and depression who presented with an altered mental status and anterograde and retrograde amnesia following kratom use. His labs showed elevated alanine aminotransferase and ammonia levels, and his MRI revealed bilateral hippocampal T2 hyperintensity signal changes.
View Article and Find Full Text PDFUnlabelled: Motivated behaviors are regulated by distributed forebrain networks. Traditional approaches have often focused on individual brain regions and connections that do not capture the topographic organization of forebrain connectivity. We performed co-injections of anterograde and retrograde tract tracers in rats to provide novel high-spatial resolution evidence of topographic connections that elaborate a previously identified closed-loop forebrain circuit implicated in affective and motivational processes.
View Article and Find Full Text PDFRadiol Case Rep
March 2025
Department of Radiology, Tenri Hospital, Nara, Japan.
We report the case of a 62-year-old male on long-term hemodialysis who was admitted to our hospital due to acute cerebral infarction associated with a cardiac calcified amorphous tumor (CAT). The patient presented with recurrent episodes of syncope and retrograde amnesia. Brain MRI identified multiple acute cerebral infarctions, while transthoracic echocardiography (TTE) revealed a 2.
View Article and Find Full Text PDFNeurogenetics
January 2025
Department of Surgery, Surgical Research Section, Hamad Medical Corporation, Doha, Qatar.
Memory is a dynamic process of encoding, storing, and retrieving information. It includes sensory, short-term, and long-term memory, each with unique characteristics. Nitric oxide (NO) is a biological messenger synthesized on demand by neuronal nitric oxide synthase (nNOS) through a biochemical process initiated by glutamate binding to NMDA receptors, causing membrane depolarization and calcium influx.
View Article and Find Full Text PDFNeurol Int
January 2025
Department of Brain Repair & Rehabilitation, Institute of Neurology, University College London, London WC1E 6BT, UK.
The differential diagnosis of acute-onset amnesia includes transient global amnesia (TGA), transient epileptic amnesia (TEA), and functional (or psychogenic) amnesia. The most common of these, TGA, is a rare but well-described condition characterised by a self-limited episode of dense anterograde amnesia with variable retrograde amnesia. Although the clinical phenomenology of TGA is well described, its pathogenesis is not currently understood, thus preventing the development of evidence-based therapeutic recommendations.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!