AI Article Synopsis
- Fulminant type 1 diabetes is a newly identified subtype characterized by extremely quick destruction of insulin-producing β-cells, leading to rapid hyperglycemia and diabetic ketoacidosis.
- A case study of a 45-year-old Chinese woman who suddenly experienced excessive thirst and urination after flu-like symptoms illustrates this condition, showing a normal HbA1c but high blood glucose and severe insulin deficiency.
- The findings suggest a possible link between HLA-DR7 and the predisposition to fulminant type 1 diabetes, particularly among Chinese individuals.
Article Abstract
Fulminant type 1 diabetes is a recently discovered subtype of idiopathic type 1 diabetes, defined as diabetes with an extremely rapid process of β-cell destruction and progression to hyperglycemia and ketoacidosis. In this report, we present a case of fulminant type 1 diabetes in a 45-year-old Chinese woman, along with a review of the literature. The patient presented with sudden onset of polydipsia and polyuria after flu-like symptoms. Findings on admission included a high blood glucose level and ketoacidosis, but normal HbA1c level. The C-peptide stimulation test showed severe impairment of insulin secretion. Autoantibodies to glutamic acid decarboxylase (GAD) were negative. These results are compatible with the diagnosis of fulminant type 1 diabetes. Human leukocyte antigen-DR7 (HLA-DR7) was available in this case. It is concluded that this rapidly progressing type of diabetes exists, and we propose that HLA-DR7 might be predisposed to fulminant type 1 diabetes in Chinese patients.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970894 | PMC |
| http://dx.doi.org/10.1631/jzus.B1000080 | DOI Listing |
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