Background: The de Morton Mobility Index (DEMMI) is an instrument that accurately measures the mobility of older people across clinical settings.
Purpose: To report the multiple reliability studies conducted during the development and validation of the DEMMI.
Methods: Intra-rater and inter-rater reliability studies were conducted for the DEMMI in two independent samples (development and validation samples) of older acute medical patients (aged 65 years or older). Inter-rater reliability studies were conducted between the test developer (a physiotherapist) and another experienced physiotherapist. Order of assessor administration was randomized by a coin toss. Patients who were fatigued after the first assessment were excluded from the inter-rater reliability study. Intra-rater reliability studies included participants with 'unchanged' mobility status between hospital admission and discharge. Scale reliability estimates were expressed as the minimal detectable change with 90% confidence (MDC90 ). Item reliability was calculated using Kappa statistics and absolute percentage agreement.
Results: The MDC90 for the DEMMI development sample was 9.51 points (95% confidence interval [95% CI], 5.04-13.32; n=21) and 7.84 (95% CI, 4.34-11.65; n=16) on the 100-point interval DEMMI scale for the inter-rater and intra-rater reliability studies, respectively. Similar estimates were obtained for the DEMMI validation samples of 8.90 (95% CI, 6.34-12.69; n=35) and 13.28 points (95% CI, 8.08-20.87; n=19). Items were not excluded from the DEMMI based on the results of item reliability.
Conclusion: Reliability estimates for the DEMMI were consistent across independent samples of older acute medical patients using different reliability study methodology. Error represents approximately 9% of the DEMMI scale width.
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http://dx.doi.org/10.1002/pri.493 | DOI Listing |
JMIR Res Protoc
January 2025
Orthopedics and Trauma Surgery, University Hospital Düsseldorf, Düsseldorf, Germany.
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January 2025
Department of Chemistry, Indian Institute of Technology Palakkad, Palakkad, Kerala 678 623, India.
The aggregation of proteins, peptides and amino acids has been a keen subject of interest owing to their implications in metabolic disorders. In this work, we investigated the self-aggregation of the unmodified aromatic amino acid l-tryptophan (Trp) into unusual spherical microstructures. Using fluorescence spectroscopy and field emission scanning electron microscopy (FE-SEM), we detail the time-dependent transformation of monomeric tryptophan into spherical aggregates with distinct fluorescence characteristics (λ = 345 nm, λ = 430 nm) compared to the monomer.
View Article and Find Full Text PDFCancer J
January 2025
From the Department of Radiation Oncology, Ohio State University Comprehensive Cancer Center, Columbus, OH.
There has been a significant paradigm shift in the clinical management of lower-grade glioma patients given the recent updates to the 2021 World Health Organization classification along with long-term results from randomized phase III clinical trials. As a result, we are now better able to diagnose and assign patients to the most appropriate treatment course. This review provides a comprehensive summary of the most robust and reliable molecular biomarkers for adult lower-grade gliomas and discusses current challenges facing this patient population that future correlative biology studies combined with advancements in technologies could help overcome.
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Vopr Virusol
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Smorodintsev Research Institute of Influenza, Ministry of Health of Russian Federation.
Introduction: Omsk hemorrhagic fever (OHF) is a severe disease identified in the 1940s in Western Siberia, Russia. Disease is caused by the OHF virus, which belongs to the genus . The purpose of the work.
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