AI Article Synopsis

  • Splanchnic vein thrombosis is a known complication in patients with polycythemia rubra vera, but the occurrence of a mobile right heart thrombus in such patients is rare.
  • A young patient with this condition developed a large mobile thrombus in the right atrium alongside bilateral pulmonary embolism after undergoing small bowel resection for ischemic bowel.
  • Despite facing complications that made treatment difficult, including a gastrointestinal bleed and contraindications for thrombolysis, the patient successfully resolved the thrombus with anticoagulation therapy.

Article Abstract

Splanchnic vein thrombosis in patients with polycythemia rubra vera is well-known. Development of mobile right heart thrombus in these patients has not been reported previously. We describe a young patient with Polycythemia rubra vera and splanchnic vein thrombosis with ischemic bowel who underwent small bowel resection. He developed a large mobile right atrial thrombus and bilateral pulmonary embolism. He also had upper gastrointestinal bleed. His management was complicated and challenging due to multiple risk factors and co-morbid conditions. Thrombolysis was contraindicated and he refused surgical intervention. He was treated with anticoagulation with complete resolution of right atrial thrombus.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964707PMC

Publication Analysis

Top Keywords

polycythemia rubra
12
rubra vera
12
splanchnic vein
12
vein thrombosis
12
mobile heart
8
heart thrombus
8
pulmonary embolism
8
patient polycythemia
8
vera splanchnic
8
atrial thrombus
8

Similar Publications

Article Synopsis
  • * Diagnosis typically involves checking for high hemoglobin levels, low erythropoietin, and the presence of a specific mutation (JAK2) to confirm the disease.
  • * A case study of a 68-year-old woman with PV showed how she developed renal artery thrombosis leading to acute kidney injury, requiring careful management of anticoagulation to balance the risks of both thrombosis and bleeding.
View Article and Find Full Text PDF

We report a case of acute myocardial infarction in a patient with polycythemia rubra vera, who has been treated with hydroxyurea. The patient presented with chest pain extending to both arms accompanied by nausea and sweating. Hemoglobin was 18.

View Article and Find Full Text PDF

Skin cancer in essential thrombocythaemia and polycythaemia vera patients treated with hydroxycarbamide.

EJHaem

November 2022

Department Haematology Aberdeen Royal Infirmary Foresterhill Health Campus Aberdeen UK.

Hydroxycarbamide (HC) is used as a cytoreductive treatment in myeloproliferative neoplasms (MPN). Observational studies have raised the possibility that HC contributes to the development of secondary malignancies, including skin tumours in MPN patients. In this retrospective observational study, we report a single-centre experience of 324 HC-treated MPN patients with long-term follow-up, compared to 47 MPN patients not on HC.

View Article and Find Full Text PDF

Polycythaemia vera (PV) is a clonal proliferative disorder of the bone marrow characterised by autonomous haematopoiesis, which results in a panmyelosis in the peripheral blood. It is typically characterised by an acquired mutation in JAK-2 V617F. Progression to myelofibrosis (MF), characterised by worsening cytopenias and the development of constitutional symptoms, is seen in up to 10% of cases.

View Article and Find Full Text PDF

There are many causes of amaurosis fugax, including polycythemia. Polycythemia is associated with elevated hematocrit levels and hyperviscosity, which can lead to ocular manifestations. We report a polycythemia patient with amaurosis fugax, who had resolution of ocular symptoms following venesection.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!