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Composite Treatment Response from a Prospective, Multi-Center Study (US-nPower) Evaluating a Miniature Spinal Cord Stimulator for the Management of Chronic, Intractable Pain.
Pain Physician
November 2024
Makous Research, LLC, Carlsbad, CA.
Article Synopsis
- Traditional pain studies have focused on single pain scores, which don't fully capture the complex effects of chronic pain on a person's daily life, mood, and overall quality of life.
- The study evaluated the Nalu™ Neurostimulation System for treating low-back and leg pain through a 90-day follow-up of patients implanted with this device at 15 pain centers in the US.
- Results showed that 94% of participants achieved meaningful improvements in at least two patient-reported outcomes, indicating the system's effectiveness in managing chronic pain.
A pilot study of novel ultrahigh-frequency dorsal root ganglia stimulation for chronic lower limb pain: Focusing on safety and feasibility.
Pain Pract
January 2025
School of Medicine, China Medical University, Taichung, Taiwan.
Objectives: This single-arm, open-label, single-center observational pilot study assessed the safety and efficacy of ultrahigh-frequency dorsal root ganglia (UHF-DRG) stimulation in patients with chronic leg pain with or without low back pain. Such high-frequency electrostimulation had not been conducted in the human central nervous system previously.
Materials And Methods: The primary objective was to evaluate the safety of UHF-DRG stimulation (2 Hz pulses with 50 msec pulse-width and 500 kHz intrapulse sine waves, 5-min duration per stimulation) by identifying incident adverse events (AE) and severe adverse events (SAE) during the trial.
Construction of nomogram for wound recurrence in elderly patients with venous leg ulcers.
Front Med (Lausanne)
October 2024
Department of Nursing, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai, China.
Background: Venous Leg Ulcers (VLUs) are one of the most serious and intractable complications of chronic venous insufficiency. This study aims to develop a nomogram based on a theoretical model to predict the probability of wound recurrence in older patients with VLUs.
Methods: The elderly patients with VLUs attending the five hospitals between September 2021 and October 2022 were enrolled in this research, and randomized to the training and validation cohorts based on the corresponding ratio (7:3).
[A Case of Combined Small Cell Lung Cancer Presenting as Malignant Psoas Syndrome].
Gan To Kagaku Ryoho
September 2024
Dept. of Thoracic Surgery, Matsuyama Shimin Hospital.
Malignant psoas syndrome(MPS)is characterized by intractable pain in the region innervating the first to fourth lumbar nerves resulting from the invasion of malignant tumors into the psoas muscle. A 57-year-old man underwent a right upper lobectomy with lymph node dissection for pStage ⅠB combined small cell lung cancer(SCLC). Adjuvant chemotherapy was subsequently administered in 2022.
View Article and Find Full Text PDFLow-energy differential target multiplexed SCS derivative reduces pain and improves quality of life through 12 months in patients with chronic back and/or leg pain.
Pain Pract
January 2025
Medtronic, Minneapolis, Minnesota, USA.
Introduction: Energy-reducing spinal cord stimulation (SCS) approaches have the potential to impact patient experience with rechargeable and non-rechargeable SCS devices through reducing device recharge time or enhancing device longevity. This prospective, multi-center study evaluated the safety, effectiveness, and actual energy usage of differential target multiplexed (DTM) endurance therapy, a reduced energy DTM SCS derivative.
Methods: Subjects who reported an overall pain visual analog score (VAS) of ≥6/10 cm and an Oswestry Disability Index score of 21-80 out of 100 at baseline with moderate to severe chronic, intractable back and/or leg pain were eligible.
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