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False-Negative Review from the Mammography Audit: Refining Breast Imaging Practice.
Radiographics
February 2025
From the Washington University School of Medicine, Mallinckrodt Institute of Radiology, 510 S Kingshighway Blvd, St. Louis, MO 63110.
Annual review of false-negative (FN) mammograms is a mandatory and critical component of the Mammography Quality Standards Act (MQSA) annual mammography audit. FN review can help hone reading skills and improve the ability to detect cancers at mammography. Subtle architectural distortion, asymmetries (seen only on one view), small lesions, lesions with probably benign appearance (circumscribed regular borders), isolated microcalcifications, and skin thickening are the most common mammographic findings when the malignancy is visible at retrospective review of FN mammograms.
View Article and Find Full Text PDFEvaluating the pathological and clinical implications of errors made by an artificial intelligence colon biopsy screening tool.
BMJ Open Gastroenterol
January 2025
Histopathology, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.
Objective: Artificial intelligence (AI) tools for histological diagnosis offer great potential to healthcare, yet failure to understand their clinical context is delaying adoption. IGUANA (Interpretable Gland-Graphs using a Neural Aggregator) is an AI algorithm that can effectively classify colonic biopsies into normal versus abnormal categories, designed to automatically report normal cases. We performed a retrospective pathological and clinical review of the errors made by IGUANA.
View Article and Find Full Text PDFQuality of Sexual Life Before and After Pelvic Organ Prolapse Surgery.
Urogynecology (Phila)
October 2024
Aava Medical Center, Hämeenlinna, Finland.
Importance: Although surgery for pelvic organ prolapse (POP) is generally associated with an improvement in sexual function, knowledge on specific changes is limited.
Objectives: The aim of this study was to describe and compare changes in sexual activity and function during a 5-year follow-up period after POP surgery.
Study Design: This was a nationwide cohort study of 3,515 women operated on for POP in 2015 in Finland.
Spatially adaptive variable screening in presurgical functional magnetic resonance imaging data analysis.
Biometrics
October 2024
Department of Statistics, North Carolina State University, Raleigh, NC 27695, United States.
Accurate delineation of functional brain regions adjacent to tumors is imperative for planning neurosurgery that preserves critical functions. Functional magnetic resonance imaging (fMRI) plays an increasingly pivotal role in presurgical counseling and planning. In the analysis of presurgical fMRI data, the impact of false negatives on patients surpasses that of false positives because failure to identify functional regions and unintentionally resecting critical tissues can result in severe harm to patients.
View Article and Find Full Text PDFValidating Rules for Defining No Improvement of Visual Acuity in Childhood Amblyopia.
Invest Ophthalmol Vis Sci
January 2025
Southern California College of Optometry at Marshall B Ketchum University, Fullerton, California, United States.
Article Synopsis
- The study emphasizes the importance of identifying when visual acuity (VA) in amblyopia patients has stabilized to inform treatment choices.
- The researchers simulated various VA measurements to assess the accuracy (false-positive and false-negative rates) of different rules for determining VA stability across multiple visits and treatments.
- Results showed significant variability in false-positive and false-negative rates depending on the measurement rules used, suggesting that clinicians should choose rules based on whether they want to minimize overlooking stabilization or misclassifying improvement.
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